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2hr9

From Proteopedia

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[[Image:2hr9.png|left|200px]]
 
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{{STRUCTURE_2hr9| PDB=2hr9 | SCENE= }}
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==Solution structure of human translationally controlled tumor protein==
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<StructureSection load='2hr9' size='340' side='right'caption='[[2hr9]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2hr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1y41 1y41]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HR9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hr9 OCA], [https://pdbe.org/2hr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hr9 RCSB], [https://www.ebi.ac.uk/pdbsum/2hr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hr9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TCTP_HUMAN TCTP_HUMAN] Involved in calcium binding and microtubule stabilization.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/2hr9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hr9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human translationally controlled tumor protein (TCTP) is a growth-related, calcium-binding protein. We determined the solution structure and backbone dynamics of human TCTP, and identified the calcium-binding site of human TCTP using multi-dimensional NMR spectroscopy. The overall structure of human TCTP has a rather rigid well-folded core and a very flexible long loop connected by a short two-strand beta-sheet, which shows a conserved fold in the TCTP family. The C-terminal portions of loop L(alpha3beta8) and strand beta9 and the N-terminal region of strand beta8 may form a calcium-binding site in the human TCTP structure, which is largely conserved in the sequence alignment of TCTPs. The K(d) value for the calcium binding is 0.022-0.025 M indicating a very weak calcium-binding site.
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===Solution structure of human translationally controlled tumor protein===
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Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR.,Feng Y, Liu D, Yao H, Wang J Arch Biochem Biophys. 2007 Nov 1;467(1):48-57. Epub 2007 Aug 30. PMID:17897616<ref>PMID:17897616</ref>
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{{ABSTRACT_PUBMED_17897616}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2hr9" style="background-color:#fffaf0;"></div>
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[[2hr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1y41 1y41]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR9 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:017897616</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Feng, Y.]]
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[[Category: Large Structures]]
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[[Category: Liu, D.]]
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[[Category: Feng Y]]
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[[Category: Wang, J.]]
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[[Category: Liu D]]
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[[Category: Yao, H.]]
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[[Category: Wang J]]
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[[Category: Apoptosis]]
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[[Category: Yao H]]
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[[Category: Metal binding protein]]
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[[Category: Tumor protein]]
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Current revision

Solution structure of human translationally controlled tumor protein

PDB ID 2hr9

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