2hr9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2hr9" [edit=sysop:move=sysop])
Current revision (19:02, 29 May 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2hr9.png|left|200px]]
 
-
{{STRUCTURE_2hr9| PDB=2hr9 | SCENE= }}
+
==Solution structure of human translationally controlled tumor protein==
 +
<StructureSection load='2hr9' size='340' side='right'caption='[[2hr9]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2hr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1y41 1y41]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HR9 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hr9 OCA], [https://pdbe.org/2hr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hr9 RCSB], [https://www.ebi.ac.uk/pdbsum/2hr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hr9 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TCTP_HUMAN TCTP_HUMAN] Involved in calcium binding and microtubule stabilization.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/2hr9_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hr9 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Human translationally controlled tumor protein (TCTP) is a growth-related, calcium-binding protein. We determined the solution structure and backbone dynamics of human TCTP, and identified the calcium-binding site of human TCTP using multi-dimensional NMR spectroscopy. The overall structure of human TCTP has a rather rigid well-folded core and a very flexible long loop connected by a short two-strand beta-sheet, which shows a conserved fold in the TCTP family. The C-terminal portions of loop L(alpha3beta8) and strand beta9 and the N-terminal region of strand beta8 may form a calcium-binding site in the human TCTP structure, which is largely conserved in the sequence alignment of TCTPs. The K(d) value for the calcium binding is 0.022-0.025 M indicating a very weak calcium-binding site.
-
===Solution structure of human translationally controlled tumor protein===
+
Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR.,Feng Y, Liu D, Yao H, Wang J Arch Biochem Biophys. 2007 Nov 1;467(1):48-57. Epub 2007 Aug 30. PMID:17897616<ref>PMID:17897616</ref>
-
{{ABSTRACT_PUBMED_17897616}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 2hr9" style="background-color:#fffaf0;"></div>
-
[[2hr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1y41 1y41]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR9 OCA].
+
== References ==
-
 
+
<references/>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:017897616</ref><references group="xtra"/>
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Feng, Y.]]
+
[[Category: Large Structures]]
-
[[Category: Liu, D.]]
+
[[Category: Feng Y]]
-
[[Category: Wang, J.]]
+
[[Category: Liu D]]
-
[[Category: Yao, H.]]
+
[[Category: Wang J]]
-
[[Category: Apoptosis]]
+
[[Category: Yao H]]
-
[[Category: Metal binding protein]]
+
-
[[Category: Tumor protein]]
+

Current revision

Solution structure of human translationally controlled tumor protein

PDB ID 2hr9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hr9"
Personal tools