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2k2d

From Proteopedia

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[[Image:2k2d.png|left|200px]]
 
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{{STRUCTURE_2k2d| PDB=2k2d | SCENE= }}
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==Solution NMR structure of C-terminal domain of human pirh2. Northeast Structural Genomics Consortium (NESG) target HT2C==
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<StructureSection load='2k2d' size='340' side='right'caption='[[2k2d]]' scene=''>
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===Solution NMR structure of C-terminal domain of human pirh2. Northeast Structural Genomics Consortium (NESG) target HT2C===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k2d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K2D FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19043414}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2d OCA], [https://pdbe.org/2k2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k2d RCSB], [https://www.ebi.ac.uk/pdbsum/2k2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2d ProSAT], [https://www.topsan.org/Proteins/NESGC/2k2d TOPSAN]</span></td></tr>
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[[2k2d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2D OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/ZN363_HUMAN ZN363_HUMAN] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.<ref>PMID:19483087</ref> <ref>PMID:16914734</ref> <ref>PMID:18006823</ref> <ref>PMID:17721809</ref> <ref>PMID:21994467</ref> <ref>PMID:21791603</ref> <ref>PMID:19043414</ref>
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<ref group="xtra">PMID:019043414</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k2d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k2d ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Duan, S.]]
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[[Category: Arrowsmith CH]]
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[[Category: Karra, M.]]
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[[Category: Duan S]]
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[[Category: Laister, R C.]]
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[[Category: Karra M]]
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[[Category: Lemak, A.]]
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[[Category: Laister RC]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Lemak A]]
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[[Category: Sheng, Y.]]
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[[Category: Sheng Y]]
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[[Category: Srisailam, S.]]
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[[Category: Srisailam S]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Nucleus]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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[[Category: Zinc-binding protein]]
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[[Category: Zinc-finger]]
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Current revision

Solution NMR structure of C-terminal domain of human pirh2. Northeast Structural Genomics Consortium (NESG) target HT2C

PDB ID 2k2d

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