2jot

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[[Image:2jot.png|left|200px]]
 
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{{STRUCTURE_2jot| PDB=2jot | SCENE= }}
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==Nuclear Magnetic Resonance Studies on Huwentoxin-XI from the Chinese Bird Spider Ornithoctonus huwena==
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<StructureSection load='2jot' size='340' side='right'caption='[[2jot]]' scene=''>
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===Nuclear Magnetic Resonance Studies on Huwentoxin-XI from the Chinese Bird Spider Ornithoctonus huwena===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2jot]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyriopagopus_schmidti Cyriopagopus schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JOT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jot OCA], [https://pdbe.org/2jot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jot RCSB], [https://www.ebi.ac.uk/pdbsum/2jot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jot ProSAT]</span></td></tr>
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[[2jot]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haplopelma_schmidti Haplopelma schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JOT OCA].
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</table>
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[[Category: Haplopelma schmidti]]
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== Function ==
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[[Category: Liang, S.]]
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[https://www.uniprot.org/uniprot/VKT1A_CYRSC VKT1A_CYRSC] Dual-function toxin that inhibits both serine proteases (trypsin) and voltage-gated potassium channels (Kv). The toxin is more active on Kv1.1/KCNA1 (78% inhibition), than on Kv1.2/KCNA2 (10% inhibition), and Kv1.3/KCNA3 (28% inhibition), although a high dose (5 uM) is needed. The inhibition of potassium channels is voltage-dependent.<ref>PMID:15066414</ref> <ref>PMID:16820861</ref>
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[[Category: Peng, K.]]
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== Evolutionary Conservation ==
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[[Category: Proteinase inhibitor]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Toxin]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jo/2jot_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jot ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cyriopagopus schmidti]]
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[[Category: Large Structures]]
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[[Category: Liang S]]
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[[Category: Peng K]]

Current revision

Nuclear Magnetic Resonance Studies on Huwentoxin-XI from the Chinese Bird Spider Ornithoctonus huwena

PDB ID 2jot

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