2gza

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[[Image:2gza.png|left|200px]]
 
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{{STRUCTURE_2gza| PDB=2gza | SCENE= }}
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==Crystal structure of the VirB11 ATPase from the Brucella Suis type IV secretion system in complex with sulphate==
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<StructureSection load='2gza' size='340' side='right'caption='[[2gza]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2gza]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_suis_1330 Brucella suis 1330]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GZA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gza OCA], [https://pdbe.org/2gza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gza RCSB], [https://www.ebi.ac.uk/pdbsum/2gza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gza ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VIRBB_BRUSU VIRBB_BRUSU] The VirB system could be required for the establishment of the replication niche in the host.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/2gza_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gza ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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VirB11 ATPases are hexameric assemblies that power type IV secretion systems in bacteria. The hexamer of Brucella suis VirB11 (BsB11), like that of the Helicobacter pylori VirB11 (Hp0525), consists of a double ring structure formed by the N-terminal and C-terminal domains of each monomer. However, the monomer differs dramatically from that of Hp0525 by a large domain swap that leaves the hexameric assembly intact but profoundly alters the nucleotide-binding site and the interface between subunits.
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===Crystal structure of the VirB11 ATPase from the Brucella Suis type IV secretion system in complex with sulphate===
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A large domain swap in the VirB11 ATPase of Brucella suis leaves the hexameric assembly intact.,Hare S, Bayliss R, Baron C, Waksman G J Mol Biol. 2006 Jun 30;360(1):56-66. Epub 2006 May 11. PMID:16730027<ref>PMID:16730027</ref>
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{{ABSTRACT_PUBMED_16730027}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2gza" style="background-color:#fffaf0;"></div>
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[[2gza]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Brucella_suis Brucella suis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GZA OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016730027</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Brucella suis]]
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[[Category: Brucella suis 1330]]
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[[Category: Baron, C.]]
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[[Category: Large Structures]]
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[[Category: Bayliss, R.]]
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[[Category: Baron C]]
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[[Category: Hare, S.]]
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[[Category: Bayliss R]]
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[[Category: Waksman, G]]
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[[Category: Hare S]]
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[[Category: Atpase]]
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[[Category: Waksman G]]
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[[Category: Hydrolase]]
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[[Category: Secretion]]
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Current revision

Crystal structure of the VirB11 ATPase from the Brucella Suis type IV secretion system in complex with sulphate

PDB ID 2gza

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