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2is9

From Proteopedia

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[[Image:2is9.png|left|200px]]
 
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{{STRUCTURE_2is9| PDB=2is9 | SCENE= }}
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==Structure of yeast DCN-1==
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<StructureSection load='2is9' size='340' side='right'caption='[[2is9]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
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===Structure of yeast DCN-1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2is9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IS9 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17597076}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2is9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2is9 OCA], [https://pdbe.org/2is9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2is9 RCSB], [https://www.ebi.ac.uk/pdbsum/2is9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2is9 ProSAT]</span></td></tr>
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[[2is9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IS9 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/DCN1_YEAST DCN1_YEAST] Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with HRT1/RBX1 to recruit the Nedd8-charged E2 UBC12 to the cullin component of SCF-type complexes.<ref>PMID:15988528</ref>
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<ref group="xtra">PMID:017597076</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/2is9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2is9 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Gao, J.]]
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[[Category: Gao J]]
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[[Category: Gong, W.]]
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[[Category: Gong W]]
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[[Category: Liu, Y.]]
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[[Category: Liu Y]]
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[[Category: Rao, Z.]]
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[[Category: Rao Z]]
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[[Category: Sun, L.]]
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[[Category: Sun L]]
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[[Category: Wei, Z.]]
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[[Category: Wei Z]]
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[[Category: Xu, R M.]]
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[[Category: Xu RM]]
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[[Category: Yang, X.]]
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[[Category: Yang X]]
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[[Category: Zhou, J.]]
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[[Category: Zhou J]]
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[[Category: Dcn1]]
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[[Category: Transcription]]
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[[Category: Ubiquitin]]
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Current revision

Structure of yeast DCN-1

PDB ID 2is9

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OCA

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