2j22

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[[Image:2j22.png|left|200px]]
 
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{{STRUCTURE_2j22| PDB=2j22 | SCENE= }}
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==Structure of a Streptococcus pneumoniae fucose binding module, SpX-3==
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<StructureSection load='2j22' size='340' side='right'caption='[[2j22]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2j22]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J22 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j22 OCA], [https://pdbe.org/2j22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j22 RCSB], [https://www.ebi.ac.uk/pdbsum/2j22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j22 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0H2US34_STRPN A0A0H2US34_STRPN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/2j22_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j22 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Streptococcus pneumoniae fucose utilization operon includes a gene encoding a virulence factor that belongs to family 98 in the glycoside hydrolase classification. This protein contains a C-terminal triplet of fucose binding modules that have significant amino acid sequence identity with the Anguilla anguilla fucolectin. Functional studies of these fucose binding modules reveal binding to fucosylated oligosaccharides and suggest the importance of multivalent binding. The high resolution crystal structures of ligand bound forms of one fucose binding module uncovers the molecular basis of fucose, ABH blood group antigen, and Lewisy antigen binding. These studies are extended by fluorescence microscopy to show specific binding to mouse lung tissue. These modules define a new family of carbohydrate binding modules now classified as family 47.
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===STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FUCOSE BINDING MODULE, SPX-3===
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Blood group antigen recognition by a Streptococcus pneumoniae virulence factor.,Boraston AB, Wang D, Burke RD J Biol Chem. 2006 Nov 17;281(46):35263-71. Epub 2006 Sep 20. PMID:16987809<ref>PMID:16987809</ref>
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{{ABSTRACT_PUBMED_16987809}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2j22" style="background-color:#fffaf0;"></div>
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[[2j22]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J22 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016987809</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Streptococcus pneumoniae]]
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[[Category: Large Structures]]
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[[Category: Boraston, A B.]]
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[[Category: Streptococcus pneumoniae TIGR4]]
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[[Category: Burke, R D.]]
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[[Category: Boraston AB]]
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[[Category: Wang, D.]]
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[[Category: Burke RD]]
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[[Category: Carbohydrate binding protein]]
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[[Category: Wang D]]
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[[Category: Carbohydrate-binding protein]]
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Current revision

Structure of a Streptococcus pneumoniae fucose binding module, SpX-3

PDB ID 2j22

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