2l81

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[[Image:2l81.png|left|200px]]
 
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{{STRUCTURE_2l81| PDB=2l81 | SCENE= }}
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==Solution NMR Structure of the serine-rich domain of hEF1 (Enhancer of filamentation 1) from Homo sapiens, Northeast Structural Genomics Consortium Target HR5554A==
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<StructureSection load='2l81' size='340' side='right'caption='[[2l81]]' scene=''>
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===Solution NMR Structure of the serine-rich domain of hEF1 (Enhancer of filamentation 1) from Homo sapiens, Northeast Structural Genomics Consortium Target HR5554A===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2l81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L81 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l81 OCA], [https://pdbe.org/2l81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l81 RCSB], [https://www.ebi.ac.uk/pdbsum/2l81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l81 ProSAT]</span></td></tr>
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[[2l81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L81 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CASL_HUMAN CASL_HUMAN] Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Ciccosanti, C T.]]
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[[Category: Acton TB]]
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[[Category: Everett, J T.]]
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[[Category: Ciccosanti CT]]
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[[Category: Huang, Y J.]]
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[[Category: Everett JT]]
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[[Category: Liu, G.]]
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[[Category: Huang YJ]]
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[[Category: Montelione, G T.]]
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[[Category: Liu G]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Patel, D.]]
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[[Category: Patel D]]
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[[Category: Tong, S.]]
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[[Category: Tong S]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Cell adhesion]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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Current revision

Solution NMR Structure of the serine-rich domain of hEF1 (Enhancer of filamentation 1) from Homo sapiens, Northeast Structural Genomics Consortium Target HR5554A

PDB ID 2l81

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