2q0j

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[[Image:2q0j.png|left|200px]]
 
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{{STRUCTURE_2q0j| PDB=2q0j | SCENE= }}
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==Structure of Pseudomonas Quinolone Signal Response Protein PqsE==
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<StructureSection load='2q0j' size='340' side='right'caption='[[2q0j]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Structure of Pseudomonas Quinolone Signal Response Protein PqsE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2q0j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q0J FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19788310}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q0j OCA], [https://pdbe.org/2q0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q0j RCSB], [https://www.ebi.ac.uk/pdbsum/2q0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q0j ProSAT]</span></td></tr>
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[[2q0j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q0J OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/PQSE_PSEAE PQSE_PSEAE] Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. Catalyzes the hydrolysis of the intermediate 2-aminobenzoylacetyl-CoA (2-ABA-CoA) to form 2-aminobenzoylacetate (2-ABA), the precursor of HHQ. In vitro, can also hydrolyze other substrates such as S-ethyl-acetothioacetate and acetoacetyl-CoA, but is inactive against anthraniloyl-CoA, malonyl-CoA and octanoyl-CoA (PubMed:25960261, PubMed:27082157). Beyond its thioesterase function, is involved in the regulation of diverse genes coding for key virulence determinants and biofilm development (PubMed:27851827).<ref>PMID:25960261</ref> <ref>PMID:27082157</ref> <ref>PMID:27851827</ref>
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<ref group="xtra">PMID:019788310</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q0/2q0j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q0j ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Blankenfeldt, W.]]
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[[Category: Blankenfeldt W]]
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[[Category: Feldmann, I.]]
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[[Category: Feldmann I]]
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[[Category: Haussler, S.]]
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[[Category: Haussler S]]
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[[Category: Jensen, V.]]
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[[Category: Jensen V]]
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[[Category: Yu, S.]]
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[[Category: Yu S]]
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[[Category: Iron]]
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[[Category: Metal binding protein]]
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[[Category: Metall-beta-lactamase]]
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[[Category: Phosphodiesterase]]
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[[Category: Pq]]
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[[Category: Pseudomonas quinolone signal]]
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[[Category: Quorum sensing]]
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Current revision

Structure of Pseudomonas Quinolone Signal Response Protein PqsE

PDB ID 2q0j

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