2rr8
From Proteopedia
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| - | [[Image:2rr8.png|left|200px]] | ||
| - | + | ==Solution structure of calponin homology domain of IQGAP1== | |
| - | + | <StructureSection load='2rr8' size='340' side='right'caption='[[2rr8]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2rr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RR8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rr8 OCA], [https://pdbe.org/2rr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2rr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rr8 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2rr8]] is a 1 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/IQGA1_HUMAN IQGA1_HUMAN] Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.<ref>PMID:15695813</ref> | |
| - | == | + | == Evolutionary Conservation == |
| - | <ref | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rr/2rr8_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rr8 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Nishida | + | [[Category: Large Structures]] |
| - | [[Category: Ogino | + | [[Category: Nishida N]] |
| - | [[Category: Shimada | + | [[Category: Ogino S]] |
| - | [[Category: Umemoto | + | [[Category: Shimada I]] |
| - | + | [[Category: Umemoto R]] | |
| - | + | ||
Current revision
Solution structure of calponin homology domain of IQGAP1
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