2wdz

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[[Image:2wdz.png|left|200px]]
 
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{{STRUCTURE_2wdz| PDB=2wdz | SCENE= }}
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==Crystal structure of the short chain dehydrogenase Galactitol- Dehydrogenase (GatDH) of Rhodobacter sphaeroides in complex with NAD+ and 1,2-Pentandiol==
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<StructureSection load='2wdz' size='340' side='right'caption='[[2wdz]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THE SHORT CHAIN DEHYDROGENASE GALACTITOL-DEHYDROGENASE (GATDH) OF RHODOBACTER SPHAEROIDES IN COMPLEX WITH NAD+ AND 1,2-PENTANDIOL===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wdz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides Cereibacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WDZ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20410293}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SP:(2S)-PENTANE-1,2-DIOL'>1SP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdz OCA], [https://pdbe.org/2wdz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wdz RCSB], [https://www.ebi.ac.uk/pdbsum/2wdz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wdz ProSAT]</span></td></tr>
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[[2wdz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDZ OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/GATDH_CERSP GATDH_CERSP] Catalyzes the interconversion of galactitol to the rare sugar L-tagatose (PubMed:7551050). Shows activity with a wide range of substrates, and catalyzes the oxidation of a variety of polyvalent aliphatic alcohols and polyols to the corresponding ketones and ketoses, respectively, and in the reverse reaction, it reduces ketones with high stereoselectivity yielding the corresponding S-configurated alcohols (PubMed:7551050, PubMed:15296184). Shows high activity with D-threitol, xylitol, 1,2-hexanediol, 1,2-pentanediol, 2-hexanol, L-erythrulose, D-ribulose and acetoin (PubMed:7551050). Specific for NAD(+) (PubMed:7551050).<ref>PMID:15296184</ref> <ref>PMID:7551050</ref>
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<ref group="xtra">PMID:020410293</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Galactitol 2-dehydrogenase]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Rhodobacter sphaeroides]]
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Check<jmol>
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[[Category: Carius, Y.]]
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<jmolCheckbox>
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[[Category: Christian, H.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wd/2wdz_consurf.spt"</scriptWhenChecked>
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[[Category: Faust, A.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Giffhorn, F.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Kohring, G W.]]
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</jmolCheckbox>
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[[Category: Kornberger, P.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wdz ConSurf].
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[[Category: Scheidig, A J.]]
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<div style="clear:both"></div>
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[[Category: Oxidoreductase]]
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== References ==
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[[Category: Rossmann fold]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cereibacter sphaeroides]]
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[[Category: Large Structures]]
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[[Category: Carius Y]]
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[[Category: Christian H]]
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[[Category: Faust A]]
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[[Category: Giffhorn F]]
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[[Category: Kohring GW]]
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[[Category: Kornberger P]]
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[[Category: Scheidig AJ]]

Current revision

Crystal structure of the short chain dehydrogenase Galactitol- Dehydrogenase (GatDH) of Rhodobacter sphaeroides in complex with NAD+ and 1,2-Pentandiol

PDB ID 2wdz

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