3b8p

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[[Image:3b8p.png|left|200px]]
 
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{{STRUCTURE_3b8p| PDB=3b8p | SCENE= }}
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==Fragment of WzzB, Polysaccharide Co-polymerase from Salmonella Typhimurium==
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<StructureSection load='3b8p' size='340' side='right'caption='[[3b8p]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3b8p]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B8P FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b8p OCA], [https://pdbe.org/3b8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b8p RCSB], [https://www.ebi.ac.uk/pdbsum/3b8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b8p ProSAT], [https://www.topsan.org/Proteins/BSGI/3b8p TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WZZB_SALTY WZZB_SALTY] Confers a modal distribution of chain length on the O-antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 20.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/3b8p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b8p ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The chain length distribution of complex polysaccharides present on the bacterial surface is determined by polysaccharide co-polymerases (PCPs) anchored in the inner membrane. We report crystal structures of the periplasmic domains of three PCPs that impart substantially different chain length distributions to surface polysaccharides. Despite very low sequence similarities, they have a common protomer structure with a long central alpha-helix extending 100 A into the periplasm. The protomers self-assemble into bell-shaped oligomers of variable sizes, with a large internal cavity. Electron microscopy shows that one of the full-length PCPs has a similar organization as that observed in the crystal for its periplasmic domain alone. Functional studies suggest that the top of the PCP oligomers is an important region for determining polysaccharide modal length. These structures provide a detailed view of components of the bacterial polysaccharide assembly machinery.
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===Fragment of WzzB, Polysaccharide Co-polymerase from Salmonella Typhimurium===
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Bacterial polysaccharide co-polymerases share a common framework for control of polymer length.,Tocilj A, Munger C, Proteau A, Morona R, Purins L, Ajamian E, Wagner J, Papadopoulos M, Van Den Bosch L, Rubinstein JL, Fethiere J, Matte A, Cygler M Nat Struct Mol Biol. 2008 Feb;15(2):130-8. Epub 2008 Jan 20. PMID:18204465<ref>PMID:18204465</ref>
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{{ABSTRACT_PUBMED_18204465}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3b8p" style="background-color:#fffaf0;"></div>
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[[3b8p]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2 Salmonella enterica subsp. enterica serovar typhimurium str. lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8P OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018204465</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium str. lt2]]
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[[Category: Large Structures]]
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[[Category: Cygler, M.]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Matte, A.]]
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[[Category: Cygler M]]
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[[Category: Tocilj, A.]]
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[[Category: Matte A]]
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[[Category: Bacterial polysaccharide co-polymerase]]
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[[Category: Tocilj A]]
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[[Category: Inner membrane]]
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[[Category: Lipopolysaccharide biosynthesis]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Transmembrane]]
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[[Category: Wzz]]
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[[Category: Wzzb]]
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Current revision

Fragment of WzzB, Polysaccharide Co-polymerase from Salmonella Typhimurium

PDB ID 3b8p

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