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2ziu

From Proteopedia

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[[Image:2ziu.png|left|200px]]
 
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{{STRUCTURE_2ziu| PDB=2ziu | SCENE= }}
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==Crystal structure of the Mus81-Eme1 complex==
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<StructureSection load='2ziu' size='340' side='right'caption='[[2ziu]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ziu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZIU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ziu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ziu OCA], [https://pdbe.org/2ziu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ziu RCSB], [https://www.ebi.ac.uk/pdbsum/2ziu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ziu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MUS81_DANRE MUS81_DANRE] Interacts with eme1 and eme2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zi/2ziu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ziu ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the Mus81-Eme1 complex===
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==See Also==
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
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{{ABSTRACT_PUBMED_18413719}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2ziu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIU OCA].
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==Reference==
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<ref group="xtra">PMID:018413719</ref><references group="xtra"/>
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[[Category: Danio rerio]]
[[Category: Danio rerio]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chang, J H.]]
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[[Category: Large Structures]]
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[[Category: Cho, Y.]]
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[[Category: Chang JH]]
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[[Category: Choi, J M.]]
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[[Category: Cho Y]]
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[[Category: Kim, J J.]]
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[[Category: Choi JM]]
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[[Category: Lee, J H.]]
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[[Category: Kim JJ]]
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[[Category: Dna damage]]
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[[Category: Lee JH]]
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[[Category: Dna recombination]]
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[[Category: Dna repair]]
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[[Category: Endonuclease]]
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[[Category: Helix-hairpin-helix]]
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[[Category: Hydrolase]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Nuclease]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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Current revision

Crystal structure of the Mus81-Eme1 complex

PDB ID 2ziu

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OCA

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