This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2z0n
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2z0n.png|left|200px]] | ||
| - | + | ==Crystal structure of APPL1-BAR domain== | |
| - | + | <StructureSection load='2z0n' size='340' side='right'caption='[[2z0n]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2z0n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Z0N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2z0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z0n OCA], [http://pdbe.org/2z0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z0n RCSB], [http://www.ebi.ac.uk/pdbsum/2z0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z0n ProSAT], [http://www.topsan.org/Proteins/RSGI/2z0n TOPSAN]</span></td></tr> |
| - | [[2z0n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Kato-Murayama, M | + | [[http://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref> |
| - | [[Category: Murayama, K | + | == Evolutionary Conservation == |
| - | [[Category: | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[Category: Sakamoto, A | + | Check<jmol> |
| - | [[Category: Shirouzu, M | + | <jmolCheckbox> |
| - | [[Category: Yokoyama, S | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/2z0n_consurf.spt"</scriptWhenChecked> |
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z0n ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kato-Murayama, M]] | ||
| + | [[Category: Murayama, K]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Sakamoto, A]] | ||
| + | [[Category: Shirouzu, M]] | ||
| + | [[Category: Yokoyama, S]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
| + | [[Category: Coiled coil]] | ||
[[Category: Endosome]] | [[Category: Endosome]] | ||
[[Category: Helix bundle]] | [[Category: Helix bundle]] | ||
| Line 23: | Line 40: | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
| - | [[Category: Structural genomic]] | ||
Current revision
Crystal structure of APPL1-BAR domain
| |||||||||||
Categories: Human | Large Structures | Kato-Murayama, M | Murayama, K | Structural genomic | Sakamoto, A | Shirouzu, M | Yokoyama, S | Cell cycle | Coiled coil | Endosome | Helix bundle | Membrane | National project on protein structural and functional analyse | Nppsfa | Nucleus | Phosphorylation | Rsgi | Signaling protein
