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3b84

From Proteopedia

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[[Image:3b84.png|left|200px]]
 
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{{STRUCTURE_3b84| PDB=3b84 | SCENE= }}
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==Crystal structure of the human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3)==
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<StructureSection load='3b84' size='340' side='right'caption='[[3b84]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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===Crystal structure of the human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3b84]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B84 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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[[3b84]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B84 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b84 OCA], [https://pdbe.org/3b84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b84 RCSB], [https://www.ebi.ac.uk/pdbsum/3b84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b84 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TZAP_HUMAN TZAP_HUMAN] Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891).<ref>PMID:24382891</ref> <ref>PMID:28082411</ref> <ref>PMID:28500257</ref> <ref>PMID:7969177</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/3b84_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b84 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bullock, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Cooper, C.]]
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[[Category: Bullock A]]
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[[Category: Delft, F von.]]
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[[Category: Cooper C]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Filippakopoulos P]]
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[[Category: Keates, T.]]
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[[Category: Keates T]]
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[[Category: Knapp, S.]]
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[[Category: Knapp S]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike ACW]]
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[[Category: Pilka, E.]]
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[[Category: Pilka E]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Salah E]]
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[[Category: Salah, E.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Activator]]
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[[Category: Btb]]
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[[Category: Dna-binding]]
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[[Category: Hkr3]]
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[[Category: Krueppel related zinc finger protein 3]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Oncogene]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zbtb48]]
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[[Category: Zinc finger]]
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[[Category: Zinc-finger]]
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Current revision

Crystal structure of the human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3)

PDB ID 3b84

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