3cuk

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[[Image:3cuk.png|left|200px]]
 
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{{STRUCTURE_3cuk| PDB=3cuk | SCENE= }}
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==Crystal structure of human D-amino acid oxidase: bound to an inhibitor==
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<StructureSection load='3cuk' size='340' side='right'caption='[[3cuk]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3cuk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CUK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4P5:4H-FURO[3,2-B]PYRROLE-5-CARBOXYLIC+ACID'>4P5</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cuk OCA], [https://pdbe.org/3cuk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cuk RCSB], [https://www.ebi.ac.uk/pdbsum/3cuk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cuk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/3cuk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cuk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The 'NMDA hypofunction hypothesis of schizophrenia' can be tested in a number of ways. DAO is the enzyme primarily responsible for the metabolism of d-serine, a co-agonist for the NMDA receptor. We identified novel DAO inhibitors, in particular, acid 1, which demonstrated moderate potency for DAO in vitro and ex vivo, and raised plasma d-serine levels after dosing ip to rats. In parallel, analogues were prepared to survey the SARs of 1.
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===Crystal structure of human D-amino acid oxidase: bound to an inhibitor===
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The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.,Sparey T, Abeywickrema P, Almond S, Brandon N, Byrne N, Campbell A, Hutson PH, Jacobson M, Jones B, Munshi S, Pascarella D, Pike A, Prasad GS, Sachs N, Sakatis M, Sardana V, Venkatraman S, Young MB Bioorg Med Chem Lett. 2008 Jun 1;18(11):3386-91. Epub 2008 Apr 13. PMID:18455394<ref>PMID:18455394</ref>
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{{ABSTRACT_PUBMED_18455394}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3cuk" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3cuk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CUK OCA].
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*[[Amino acid oxidase 3D structures|Amino acid oxidase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018455394</ref><references group="xtra"/>
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__TOC__
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[[Category: D-amino-acid oxidase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Munshi, S.]]
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[[Category: Large Structures]]
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[[Category: Prasad, S.]]
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[[Category: Munshi S]]
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[[Category: Alpha-beta-alpha motif]]
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[[Category: Prasad S]]
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[[Category: Fad]]
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[[Category: Flavin containing protein]]
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[[Category: Flavin containing proteinalpha-beta-alpha motif]]
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[[Category: Flavoprotein]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxisome]]
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Current revision

Crystal structure of human D-amino acid oxidase: bound to an inhibitor

PDB ID 3cuk

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