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1x5p

From Proteopedia

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[[Image:1x5p.gif|left|200px]]<br /><applet load="1x5p" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1x5p" />
 
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'''Solution structure of RRM domain in Parp14'''<br />
 
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==Disease==
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==Solution structure of RRM domain in Parp14==
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Known diseases associated with this structure: Blood group, Radin OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609017 609017]], Blood group, Scianna system OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609017 609017]]
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<StructureSection load='1x5p' size='340' side='right'caption='[[1x5p]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1x5p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5P FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5p OCA], [https://pdbe.org/1x5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5p RCSB], [https://www.ebi.ac.uk/pdbsum/1x5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5p ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5p TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NELFE_HUMAN NELFE_HUMAN] Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.<ref>PMID:10199401</ref> <ref>PMID:11940650</ref> <ref>PMID:12612062</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x5/1x5p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x5p ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1X5P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5P OCA].
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*[[Negative elongation factor|Negative elongation factor]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dang, W.]]
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[[Category: Dang W]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y.]]
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[[Category: Muto Y]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M.]]
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[[Category: Terada T]]
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[[Category: Terada, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: national project on protein structural and functional analyses]]
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[[Category: nmr]]
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[[Category: nppsfa]]
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[[Category: parp14]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rrm domain]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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[[Category: structure genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:51:17 2008''
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Current revision

Solution structure of RRM domain in Parp14

PDB ID 1x5p

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