1x6b
From Proteopedia
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| - | [[Image:1x6b.gif|left|200px]]<br /><applet load="1x6b" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1x6b" /> | ||
| - | '''Solution structures of the SH3 domain of human rho guanine exchange factor (GEF) 16'''<br /> | ||
| - | == | + | ==Solution structures of the SH3 domain of human rho guanine exchange factor (GEF) 16== |
| - | + | <StructureSection load='1x6b' size='340' side='right'caption='[[1x6b]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | [[ | + | <table><tr><td colspan='2'>[[1x6b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X6B FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x6b OCA], [https://pdbe.org/1x6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x6b RCSB], [https://www.ebi.ac.uk/pdbsum/1x6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x6b ProSAT], [https://www.topsan.org/Proteins/RSGI/1x6b TOPSAN]</span></td></tr> |
| - | [ | + | </table> |
| - | + | == Function == | |
| - | [ | + | [https://www.uniprot.org/uniprot/ARHGG_HUMAN ARHGG_HUMAN] Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.<ref>PMID:20679435</ref> |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | [ | + | <jmolCheckbox> |
| - | [[ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x6/1x6b_consurf.spt"</scriptWhenChecked> |
| - | [ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [ | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x6b ConSurf]. | |
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Inoue M]] | ||
| + | [[Category: Kigawa T]] | ||
| + | [[Category: Koshiba S]] | ||
| + | [[Category: Saito K]] | ||
| + | [[Category: Sato M]] | ||
| + | [[Category: Yokoyama S]] | ||
Current revision
Solution structures of the SH3 domain of human rho guanine exchange factor (GEF) 16
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Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Koshiba S | Saito K | Sato M | Yokoyama S
