2rap

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[[Image:2rap.png|left|200px]]
 
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{{STRUCTURE_2rap| PDB=2rap | SCENE= }}
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==THE SMALL G PROTEIN RAP2A IN COMPLEX WITH GTP==
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<StructureSection load='2rap' size='340' side='right'caption='[[2rap]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===THE SMALL G PROTEIN RAP2A IN COMPLEX WITH GTP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2rap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RAP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9312017}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rap OCA], [https://pdbe.org/2rap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rap RCSB], [https://www.ebi.ac.uk/pdbsum/2rap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rap ProSAT]</span></td></tr>
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[[2rap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RAP OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/RAP2A_HUMAN RAP2A_HUMAN] Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.<ref>PMID:14966141</ref> <ref>PMID:15342639</ref> <ref>PMID:16246175</ref> <ref>PMID:16540189</ref> <ref>PMID:18930710</ref> <ref>PMID:20159449</ref>
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<ref group="xtra">PMID:009312017</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ra/2rap_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rap ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cherfils, J.]]
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[[Category: Large Structures]]
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[[Category: Lebras, G.]]
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[[Category: Cherfils J]]
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[[Category: Menetrey, J.]]
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[[Category: Lebras G]]
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[[Category: G protein]]
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[[Category: Menetrey J]]
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[[Category: Gtp hydrolysis]]
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[[Category: Rap2a]]
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[[Category: Ra]]
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Current revision

THE SMALL G PROTEIN RAP2A IN COMPLEX WITH GTP

PDB ID 2rap

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