3ber

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[[Image:3ber.png|left|200px]]
 
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{{STRUCTURE_3ber| PDB=3ber | SCENE= }}
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==Human DEAD-box RNA-helicase DDX47, conserved domain I in complex with AMP==
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<StructureSection load='3ber' size='340' side='right'caption='[[3ber]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ber]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BER FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ber FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ber OCA], [https://pdbe.org/3ber PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ber RCSB], [https://www.ebi.ac.uk/pdbsum/3ber PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ber ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DDX47_HUMAN DDX47_HUMAN] Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors.<ref>PMID:15977068</ref> <ref>PMID:16963496</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/3ber_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ber ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are involved. Members of this family of proteins are linked to human disease, including cancer and viral infections. DEAD-box proteins contain two conserved domains that both contribute to RNA and ATP binding. Despite recent advances the molecular details of how these enzymes convert chemical energy into RNA remodeling is unknown. We present crystal structures of the isolated DEAD-domains of human DDX2A/eIF4A1, DDX2B/eIF4A2, DDX5, DDX10/DBP4, DDX18/myc-regulated DEAD-box protein, DDX20, DDX47, DDX52/ROK1, and DDX53/CAGE, and of the helicase domains of DDX25 and DDX41. Together with prior knowledge this enables a family-wide comparative structural analysis. We propose a general mechanism for opening of the RNA binding site. This analysis also provides insights into the diversity of DExD/H- proteins, with implications for understanding the functions of individual family members.
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===Human DEAD-box RNA-helicase DDX47, conserved domain I in complex with AMP===
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Comparative structural analysis of human DEAD-box RNA helicases.,Schutz P, Karlberg T, van den Berg S, Collins R, Lehtio L, Hogbom M, Holmberg-Schiavone L, Tempel W, Park HW, Hammarstrom M, Moche M, Thorsell AG, Schuler H PLoS One. 2010 Sep 30;5(9). pii: e12791. PMID:20941364<ref>PMID:20941364</ref>
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{{ABSTRACT_PUBMED_20941364}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ber" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3ber]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BER OCA].
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*[[Helicase 3D structures|Helicase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020941364</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Berg, S Van Den.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berglund, H.]]
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[[Category: Berglund H]]
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[[Category: Busam, R D.]]
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[[Category: Busam RD]]
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[[Category: Collins, R.]]
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[[Category: Collins R]]
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[[Category: Dahlgren, L G.]]
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[[Category: Dahlgren LG]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Flodin, S.]]
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[[Category: Flodin S]]
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[[Category: Flores, A.]]
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[[Category: Flores A]]
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[[Category: Graslund, S.]]
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[[Category: Graslund S]]
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[[Category: Hammarstrom, M.]]
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[[Category: Hammarstrom M]]
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[[Category: Holmberg-Schiavone, L.]]
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[[Category: Holmberg-Schiavone L]]
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[[Category: Johansson, I.]]
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[[Category: Johansson I]]
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[[Category: Kallas, A.]]
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[[Category: Kallas A]]
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[[Category: Karlberg, T.]]
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[[Category: Karlberg T]]
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[[Category: Kotenyova, T.]]
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[[Category: Kotenyova T]]
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[[Category: Lehtio, L.]]
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[[Category: Lehtio L]]
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[[Category: Moche, M.]]
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[[Category: Moche M]]
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[[Category: Nilsson, M E.]]
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[[Category: Nilsson ME]]
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[[Category: Nordlund, P.]]
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[[Category: Nordlund P]]
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[[Category: Nyman, T.]]
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[[Category: Nyman T]]
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[[Category: Persson, C.]]
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[[Category: Persson C]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sagemark J]]
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[[Category: Sagemark, J.]]
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[[Category: Svensson L]]
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[[Category: Svensson, L.]]
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[[Category: Thorsell AG]]
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[[Category: Thorsell, A G.]]
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[[Category: Tresaugues L]]
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[[Category: Tresaugues, L.]]
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[[Category: Van Den Berg S]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Welin, M.]]
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[[Category: Welin M]]
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[[Category: Amp]]
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[[Category: Atp-binding]]
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[[Category: Dead]]
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[[Category: Hydrolase]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Rna helicase]]
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[[Category: Rna-binding]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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Current revision

Human DEAD-box RNA-helicase DDX47, conserved domain I in complex with AMP

PDB ID 3ber

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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