3b4r

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m (Protected "3b4r" [edit=sysop:move=sysop])
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[[Image:3b4r.png|left|200px]]
 
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{{STRUCTURE_3b4r| PDB=3b4r | SCENE= }}
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==Site-2 Protease from Methanocaldococcus jannaschii==
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<StructureSection load='3b4r' size='340' side='right'caption='[[3b4r]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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===Site-2 Protease from Methanocaldococcus jannaschii===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3b4r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. The August 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Rhomboid Protease GlpG'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_8 10.2210/rcsb_pdb/mom_2011_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B4R FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18063795}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b4r OCA], [https://pdbe.org/3b4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b4r RCSB], [https://www.ebi.ac.uk/pdbsum/3b4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b4r ProSAT]</span></td></tr>
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[[3b4r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. The August 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Rhomboid Protease GlpG'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_8 10.2210/rcsb_pdb/mom_2011_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4R OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/Y392_METJA Y392_METJA] A site-2 regulated intramembrane protease (S2P), its endogenous substrate is unknown. Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. A membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this enzyme), while cytoplasmic proteases finish degrading the regulatory protein, liberating the effector protein. Possible signals, S1P and substrates are unknown in this organism.
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<ref group="xtra">PMID:018063795</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/3b4r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b4r ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Rhomboid Protease GlpG]]
[[Category: Rhomboid Protease GlpG]]
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[[Category: Feng, L.]]
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[[Category: Feng L]]
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[[Category: Jeffrey, P D.]]
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[[Category: Jeffrey PD]]
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[[Category: Shi, Y.]]
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[[Category: Shi Y]]
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[[Category: Wang, Z.]]
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[[Category: Wang Z]]
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[[Category: Wu, Z.]]
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[[Category: Wu Z]]
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[[Category: Yan, H.]]
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[[Category: Yan H]]
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[[Category: Yan, N.]]
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[[Category: Yan N]]
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[[Category: Cbs domain]]
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[[Category: Hydrolase]]
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[[Category: Intramembrane protease]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotease]]
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[[Category: Transmembrane]]
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Current revision

Site-2 Protease from Methanocaldococcus jannaschii

PDB ID 3b4r

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