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2vkq

From Proteopedia

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[[Image:2vkq.png|left|200px]]
 
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{{STRUCTURE_2vkq| PDB=2vkq | SCENE= }}
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==Crystal structure of human cytosolic 5'-nucleotidase III (cN-III, NT5C3) in complex with beryllium trifluoride==
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<StructureSection load='2vkq' size='340' side='right'caption='[[2vkq]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE III (CN-III, NT5C3) IN COMPLEX WITH BERYLLIUM TRIFLUORIDE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2vkq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VKQ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17405878}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkq OCA], [https://pdbe.org/2vkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vkq RCSB], [https://www.ebi.ac.uk/pdbsum/2vkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkq ProSAT]</span></td></tr>
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[[2vkq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKQ OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/5NT3A_HUMAN 5NT3A_HUMAN] Hemolytic anemia due to pyrimidine 5' nucleotidase deficiency. The disease is caused by variants affecting the gene represented in this entry.
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<ref group="xtra">PMID:017405878</ref><references group="xtra"/>
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== Function ==
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[[Category: 5'-nucleotidase]]
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[https://www.uniprot.org/uniprot/5NT3A_HUMAN 5NT3A_HUMAN] Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458).<ref>PMID:15968458</ref> <ref>PMID:24603684</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vkq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vkq ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Berg, S Van Den.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berglund, H.]]
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[[Category: Berglund H]]
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[[Category: Busam, R.]]
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[[Category: Busam R]]
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[[Category: Collins, R.]]
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[[Category: Collins R]]
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[[Category: Dahlgren, L G.]]
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[[Category: Dahlgren LG]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Flodin, S.]]
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[[Category: Flodin S]]
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[[Category: Flores, A.]]
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[[Category: Flores A]]
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[[Category: Graslund, S.]]
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[[Category: Graslund S]]
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[[Category: Hammarstrom, M.]]
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[[Category: Hammarstrom M]]
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[[Category: Herman, M D.]]
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[[Category: Herman MD]]
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[[Category: Johansson, A.]]
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[[Category: Johansson A]]
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[[Category: Johansson, I.]]
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[[Category: Johansson I]]
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[[Category: Kallas, A.]]
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[[Category: Kallas A]]
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[[Category: Karlberg, T.]]
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[[Category: Karlberg T]]
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[[Category: Kotenyova, T.]]
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[[Category: Kotenyova T]]
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[[Category: Lehtio, L.]]
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[[Category: Lehtio L]]
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[[Category: Moche, M.]]
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[[Category: Moche M]]
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[[Category: Nilsson, M E.]]
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[[Category: Nilsson ME]]
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[[Category: Nordlund, P.]]
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[[Category: Nordlund P]]
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[[Category: Nyman, T.]]
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[[Category: Nyman T]]
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[[Category: Persson, C.]]
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[[Category: Persson C]]
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[[Category: Sagemark, J.]]
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[[Category: Sagemark J]]
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[[Category: Sgc, Structural GenomicsConsortium.]]
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[[Category: Thorsell AG]]
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[[Category: Thorsell, A G.]]
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[[Category: Tresaugues L]]
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[[Category: Tresaugues, L.]]
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[[Category: Wallden K]]
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[[Category: Wallden, K.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Welin M]]
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[[Category: Welin, M.]]
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[[Category: Van den Berg S]]
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[[Category: Disease mutation]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Hemolytic anemia]]
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[[Category: Hydrolase]]
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[[Category: Nucleotidase]]
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[[Category: Nucleotide metabolism]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphotransferase]]
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Current revision

Crystal structure of human cytosolic 5'-nucleotidase III (cN-III, NT5C3) in complex with beryllium trifluoride

PDB ID 2vkq

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