2x29

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[[Image:2x29.png|left|200px]]
 
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{{STRUCTURE_2x29| PDB=2x29 | SCENE= }}
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==Crystal structure of human4-1BB ligand ectodomain==
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<StructureSection load='2x29' size='340' side='right'caption='[[2x29]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2x29]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2wak 2wak]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X29 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x29 OCA], [https://pdbe.org/2x29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x29 RCSB], [https://www.ebi.ac.uk/pdbsum/2x29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x29 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/TNFL9_HUMAN TNFL9_HUMAN]] Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/2x29_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x29 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Binding of the 4-1BB ligand (4-1BBL) to its receptor, 4-1BB, provides the T lymphocyte with co-stimulatory signals for survival, proliferation, and differentiation. Importantly, the 4-1BB-4-1BBL pathway is a well known target for anti-cancer immunotherapy. Here we present the 2.3-A crystal structure of the extracellular domain of human 4-1BBL. The ectodomain forms a homotrimer with an extended, three-bladed propeller structure that differs from trimers formed by other members of the tumor necrosis factor (TNF) superfamily. Based on the 4-1BBL structure, we modeled its complex with 4-1BB, which was consistent with images obtained by electron microscopy, and verified the binding site by site-directed mutagenesis. This structural information will facilitate the development of immunotherapeutics targeting 4-1BB.
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===CRYSTAL STRUCTURE OF HUMAN4-1BB LIGAND ECTODOMAIN===
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The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily.,Won EY, Cha K, Byun JS, Kim DU, Shin S, Ahn B, Kim YH, Rice AJ, Walz T, Kwon BS, Cho HS J Biol Chem. 2010 Mar 19;285(12):9202-10. Epub 2009 Dec 23. PMID:20032458<ref>PMID:20032458</ref>
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{{ABSTRACT_PUBMED_20032458}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2x29" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2x29]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2wak 2wak]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X29 OCA].
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*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020032458</ref><references group="xtra"/>
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__TOC__
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[[Category: Homo sapiens]]
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</StructureSection>
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[[Category: Cho, H S.]]
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[[Category: Human]]
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[[Category: Won, E Y.]]
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[[Category: Large Structures]]
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[[Category: Cho, H S]]
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[[Category: Won, E Y]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
[[Category: Cytokine]]
[[Category: Cytokine]]
[[Category: Signal-anchor]]
[[Category: Signal-anchor]]

Current revision

Crystal structure of human4-1BB ligand ectodomain

PDB ID 2x29

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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