3cxq

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[[Image:3cxq.png|left|200px]]
 
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{{STRUCTURE_3cxq| PDB=3cxq | SCENE= }}
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==Crystal structure of human glucosamine 6-phosphate N-acetyltransferase 1 bound to GlcN6P==
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<StructureSection load='3cxq' size='340' side='right'caption='[[3cxq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3cxq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CXQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLP:GLUCOSAMINE+6-PHOSPHATE'>GLP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxq OCA], [https://pdbe.org/3cxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cxq RCSB], [https://www.ebi.ac.uk/pdbsum/3cxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GNA1_HUMAN GNA1_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cxq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cxq ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glucosamine-6-phosphate (GlcN6P) N-acetyltransferase 1 (GNA1) is a key enzyme in the pathway toward biosynthesis of UDP-N-acetylglucosamine, an important donor substrate for N-linked glycosylation. GNA1 catalyzes the formation of N-acetylglucosamine-6-phosphate (GlcNAc6P) from acetyl-CoA (AcCoA) and the acceptor substrate GlcN6P. Here, we report crystal structures of human GNA1, including apo GNA1, the GNA1-GlcN6P complex and an E156A mutant. Our work showed that GlcN6P binds to GNA1 without the help of AcCoA binding. Structural analyses and mutagenesis studies have shed lights on the charge distribution in the GlcN6P binding pocket, and an important role for Glu156 in the substrate binding. Hence, these findings have broadened our knowledge of structural features required for the substrate affinity of GNA1.
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===Crystal structure of human glucosamine 6-phosphate N-acetyltransferase 1 bound to GlcN6P===
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Acceptor substrate binding revealed by crystal structure of human glucosamine-6-phosphate N-acetyltransferase 1.,Wang J, Liu X, Liang YH, Li LF, Su XD FEBS Lett. 2008 Sep 3;582(20):2973-8. Epub 2008 Aug 7. PMID:18675810<ref>PMID:18675810</ref>
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{{ABSTRACT_PUBMED_18675810}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3cxq" style="background-color:#fffaf0;"></div>
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[[3cxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXQ OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018675810</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Glucosamine-phosphate N-acetyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, L F.]]
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[[Category: Large Structures]]
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[[Category: Liu, X.]]
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[[Category: Li L-F]]
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[[Category: Su, X D.]]
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[[Category: Liu X]]
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[[Category: Wang, J.]]
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[[Category: Su X-D]]
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[[Category: Acyltransferase]]
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[[Category: Wang J]]
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[[Category: Endosome]]
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[[Category: Glucosamine 6-phosphate n-acetyltransferase 1]]
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[[Category: Golgi apparatus]]
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[[Category: Membrane]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human glucosamine 6-phosphate N-acetyltransferase 1 bound to GlcN6P

PDB ID 3cxq

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