2zmh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:57, 13 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2zmh.png|left|200px]]
 
-
{{STRUCTURE_2zmh| PDB=2zmh | SCENE= }}
+
==Crystal Structure of Rat Vitamin D Receptor Bound to Adamantyl Vitamin D Analogs: Structural Basis for Vitamin D Receptor Antagonism and/or Partial Agonism==
 +
<StructureSection load='2zmh' size='340' side='right'caption='[[2zmh]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2zmh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZMH FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NYA:(1R,3R,7E,17BETA)-17-{(1R,2E,4R)-4-HYDROXY-1-METHYL-4-[(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DEC-1-YL]BUT-2-EN-1-YL}-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>NYA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zmh OCA], [https://pdbe.org/2zmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zmh RCSB], [https://www.ebi.ac.uk/pdbsum/2zmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zmh ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zm/2zmh_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zmh ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal Structure of Rat Vitamin D Receptor Bound to Adamantyl Vitamin D Analogs: Structural Basis for Vitamin D Receptor Antagonism and/or Partial Agonism===
+
==See Also==
-
 
+
*[[Sandbox vdr|Sandbox vdr]]
-
{{ABSTRACT_PUBMED_18710208}}
+
*[[Vitamin D receptor 3D structures|Vitamin D receptor 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
[[2zmh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZMH OCA].
+
__TOC__
-
 
+
</StructureSection>
-
==Reference==
+
[[Category: Large Structures]]
-
<ref group="xtra">PMID:018710208</ref><references group="xtra"/>
+
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: DeLuca, H F.]]
+
[[Category: Xenopus tropicalis]]
-
[[Category: Igarashi, M.]]
+
[[Category: DeLuca HF]]
-
[[Category: Ikura, T.]]
+
[[Category: Igarashi M]]
-
[[Category: Ito, N.]]
+
[[Category: Ikura T]]
-
[[Category: Makishima, M.]]
+
[[Category: Ito N]]
-
[[Category: Nakabayashi, M.]]
+
[[Category: Makishima M]]
-
[[Category: Shimizu, M.]]
+
[[Category: Nakabayashi M]]
-
[[Category: Tanaka, T.]]
+
[[Category: Shimizu M]]
-
[[Category: Tokiwa, H.]]
+
[[Category: Tanaka T]]
-
[[Category: Yamada, S.]]
+
[[Category: Tokiwa H]]
-
[[Category: Yoshimoto, N.]]
+
[[Category: Yamada S]]
-
[[Category: Activator]]
+
[[Category: Yoshimoto N]]
-
[[Category: Dna-binding]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Nuclear receptor-antagonist complex]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription regulation]]
+
-
[[Category: Zinc-finger]]
+

Current revision

Crystal Structure of Rat Vitamin D Receptor Bound to Adamantyl Vitamin D Analogs: Structural Basis for Vitamin D Receptor Antagonism and/or Partial Agonism

PDB ID 2zmh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2zmh"
Personal tools