2r0d

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[[Image:2r0d.png|left|200px]]
 
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{{STRUCTURE_2r0d| PDB=2r0d | SCENE= }}
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==Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor==
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<StructureSection load='2r0d' size='340' side='right'caption='[[2r0d]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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===Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2r0d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R0D FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18042453}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4IP:INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE'>4IP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0d OCA], [https://pdbe.org/2r0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r0d RCSB], [https://www.ebi.ac.uk/pdbsum/2r0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r0d ProSAT]</span></td></tr>
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[[2r0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0D OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/CYH3_MOUSE CYH3_MOUSE] Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP.<ref>PMID:18042453</ref>
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<ref group="xtra">PMID:018042453</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r0/2r0d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r0d ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Cronin, T C.]]
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[[Category: Cronin TC]]
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[[Category: Czech, M P.]]
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[[Category: Czech MP]]
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[[Category: Delprato, A.]]
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[[Category: Delprato A]]
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[[Category: DiNitto, J P.]]
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[[Category: DiNitto JP]]
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[[Category: Guilherme, A.]]
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[[Category: Gabe Lee MT]]
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[[Category: Huang, S.]]
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[[Category: Guilherme A]]
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[[Category: Lambright, D G.]]
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[[Category: Huang S]]
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[[Category: Lee, M T.Gabe.]]
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[[Category: Lambright DG]]
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[[Category: 3-phosphoinositide]]
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[[Category: Arf gtpase]]
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[[Category: Exchange factor]]
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[[Category: General receptor for phosphoinositide]]
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[[Category: Grp1]]
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[[Category: Guanine-nucleotide releasing factor]]
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[[Category: Pip3]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor

PDB ID 2r0d

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