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2rer
From Proteopedia
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| - | [[Image:2rer.png|left|200px]] | ||
| - | + | ==Crystal structure of the aromatase/cyclase domain of TcmN from Streptomyces glaucescens== | |
| - | + | <StructureSection load='2rer' size='340' side='right'caption='[[2rer]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2rer]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_glaucescens Streptomyces glaucescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RER FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rer OCA], [https://pdbe.org/2rer PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rer RCSB], [https://www.ebi.ac.uk/pdbsum/2rer PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rer ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2rer]] is a 1 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/TCMN_STRGA TCMN_STRGA] The N-terminal domain enhances the formation of an early, partially cyclized intermediate, while the C-terminal domain catalyzes the 3-O-methylation of one or more later intermediates in the biosynthetic pathway. Catalyzes the methylation of tetracenomycin D3 (Tcm D3) to yield Tcm B3. Catalyzes as well the following side reactions: methylation of 8-O-methyl-Tcm D3 to yield Tcm E; and of 9-carboxymethyl-Tcm B3 to yield Tcm A2. | |
| - | == | + | == Evolutionary Conservation == |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/2rer_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rer ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Streptomyces glaucescens]] | [[Category: Streptomyces glaucescens]] | ||
| - | [[Category: Ames | + | [[Category: Ames BD]] |
| - | [[Category: Korman | + | [[Category: Korman TP]] |
| - | [[Category: Tsai | + | [[Category: Tsai SC]] |
| - | [[Category: Vu | + | [[Category: Vu TN]] |
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Current revision
Crystal structure of the aromatase/cyclase domain of TcmN from Streptomyces glaucescens
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