2xy1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:01, 1 February 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2xy1.png|left|200px]]
 
-
{{STRUCTURE_2xy1| PDB=2xy1 | SCENE= }}
+
==CRYSTAL STRUCTURE OF NCAM2 IG3-4==
 +
<StructureSection load='2xy1' size='340' side='right'caption='[[2xy1]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2xy1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2va4 2va4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XY1 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.979&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xy1 OCA], [https://pdbe.org/2xy1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xy1 RCSB], [https://www.ebi.ac.uk/pdbsum/2xy1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xy1 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NCAM2_HUMAN NCAM2_HUMAN] May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The ectodomain of olfactory cell adhesion molecule (OCAM/NCAM2/RNCAM) consists of five immunoglobulin (Ig) domains (IgI-V), followed by two fibronectin-type 3 (Fn3) domains (Fn3I-II). A complete structural model of the entire ectodomain of human OCAM has been assembled from crystal structures of six recombinant proteins corresponding to different regions of the ectodomain. The model is the longest experimentally based composite structural model of an entire IgCAM ectodomain. It displays an essentially linear arrangement of IgI-V, followed by bends between IgV and Fn3I and between Fn3I and Fn3II. Proteins containing IgI-IgII domains formed stable homodimers in solution and in crystals. Dimerization could be disrupted in vitro by mutations in the dimer interface region. In conjunction with the bent ectodomain conformation, which can position IgI-V parallel with the cell surface, the IgI-IgII dimerization enables OCAM-mediated trans-interactions with an intercellular distance of about 20 nm, which is consistent with that observed in synapses.
-
===CRYSTAL STRUCTURE OF NCAM2 IG3-4===
+
Structural Model and trans-Interaction of the Entire Ectodomain of the Olfactory Cell Adhesion Molecule.,Kulahin N, Kristensen O, Rasmussen KK, Olsen L, Rydberg P, Vestergaard B, Kastrup JS, Berezin V, Bock E, Walmod PS, Gajhede M Structure. 2011 Feb 9;19(2):203-11. PMID:21300289<ref>PMID:21300289</ref>
-
{{ABSTRACT_PUBMED_21300289}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 2xy1" style="background-color:#fffaf0;"></div>
-
[[2xy1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2va4 2va4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XY1 OCA].
+
== References ==
-
 
+
<references/>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:021300289</ref><references group="xtra"/>
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Berezin, V.]]
+
[[Category: Large Structures]]
-
[[Category: Bock, E.]]
+
[[Category: Berezin V]]
-
[[Category: Gajhede, M.]]
+
[[Category: Bock E]]
-
[[Category: Kristensen, O.]]
+
[[Category: Gajhede M]]
-
[[Category: Kulahin, N.]]
+
[[Category: Kristensen O]]
-
[[Category: Rasmussen, K K.]]
+
[[Category: Kulahin N]]
-
[[Category: Walmod, P S.]]
+
[[Category: Rasmussen KK]]
-
[[Category: Cell adhesion]]
+
[[Category: Walmod PS]]

Current revision

CRYSTAL STRUCTURE OF NCAM2 IG3-4

PDB ID 2xy1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2xy1"
Personal tools