2w80

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[[Image:2w80.png|left|200px]]
 
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{{STRUCTURE_2w80| PDB=2w80 | SCENE= }}
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==Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H==
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<StructureSection load='2w80' size='340' side='right'caption='[[2w80]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2w80]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W80 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w80 OCA], [https://pdbe.org/2w80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w80 RCSB], [https://www.ebi.ac.uk/pdbsum/2w80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w80 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FHBP_NEIMB FHBP_NEIMB] A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH), binding contributes to the avoidance of complement-mediated lysis by N.meningitidis. Binding of fH to the bacteria surface is independent of bacterial sialic acid moieties (PubMed:16751403). fH binding affinity is high enough that it may sequester plasma fH, depleting its circulating levels and de-regulating complement in the host (Probable). This protein induces high levels of bactericidal antibodies in mice (PubMed:12642606, PubMed:15039331, PubMed:15664958, PubMed:21753121, PubMed:23133374).<ref>PMID:12642606</ref> <ref>PMID:15039331</ref> <ref>PMID:15664958</ref> <ref>PMID:16751403</ref> <ref>PMID:21753121</ref> <ref>PMID:23133374</ref> <ref>PMID:19225461</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w8/2w80_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w80 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The complement system is an essential component of the innate and acquired immune system, and consists of a series of proteolytic cascades that are initiated by the presence of microorganisms. In health, activation of complement is precisely controlled through membrane-bound and soluble plasma-regulatory proteins including complement factor H (fH; ref. 2), a 155 kDa protein composed of 20 domains (termed complement control protein repeats). Many pathogens have evolved the ability to avoid immune-killing by recruiting host complement regulators and several pathogens have adapted to avoid complement-mediated killing by sequestering fH to their surface. Here we present the structure of a complement regulator in complex with its pathogen surface-protein ligand. This reveals how the important human pathogen Neisseria meningitidis subverts immune responses by mimicking the host, using protein instead of charged-carbohydrate chemistry to recruit the host complement regulator, fH. The structure also indicates the molecular basis of the host-specificity of the interaction between fH and the meningococcus, and informs attempts to develop novel therapeutics and vaccines.
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===STRUCTURE OF A COMPLEX BETWEEN NEISSERIA MENINGITIDIS FACTOR H BINDING PROTEIN AND CCPS 6-7 OF HUMAN COMPLEMENT FACTOR H===
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Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates.,Schneider MC, Prosser BE, Caesar JJ, Kugelberg E, Li S, Zhang Q, Quoraishi S, Lovett JE, Deane JE, Sim RB, Roversi P, Johnson S, Tang CM, Lea SM Nature. 2009 Apr 16;458(7240):890-3. Epub 2009 Feb 18. PMID:19225461<ref>PMID:19225461</ref>
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{{ABSTRACT_PUBMED_19225461}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2w80" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2w80]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W80 OCA].
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*[[Complement factor 3D structures|Complement factor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019225461</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Neisseria meningitidis]]
[[Category: Neisseria meningitidis]]
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[[Category: Caesar, J J.E.]]
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[[Category: Caesar JJE]]
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[[Category: Deane, J E.]]
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[[Category: Deane JE]]
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[[Category: Johnson, S.]]
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[[Category: Johnson S]]
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[[Category: Kugelberg, E.]]
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[[Category: Kugelberg E]]
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[[Category: Lea, S M.]]
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[[Category: Lea SM]]
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[[Category: Li, S.]]
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[[Category: Li S]]
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[[Category: Lovett, J E.]]
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[[Category: Lovett JE]]
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[[Category: Prosser, B E.]]
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[[Category: Prosser BE]]
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[[Category: Quoraishi, S.]]
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[[Category: Quoraishi S]]
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[[Category: Roversi, P.]]
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[[Category: Roversi P]]
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[[Category: Schneider, M C.]]
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[[Category: Schneider MC]]
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[[Category: Sim, R B.]]
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[[Category: Sim RB]]
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[[Category: Tang, C M.]]
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[[Category: Tang CM]]
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[[Category: Zhang, Q.]]
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[[Category: Zhang Q]]
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[[Category: Age-related macular degeneration]]
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[[Category: Complement alternate pathway]]
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[[Category: Disease mutation]]
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[[Category: Factor h]]
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[[Category: Glycoprotein]]
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[[Category: Immune evasion]]
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[[Category: Immune response]]
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[[Category: Immune system]]
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[[Category: Innate immunity]]
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[[Category: Vaccine candidate]]
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Current revision

Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H

PDB ID 2w80

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