2qze
From Proteopedia
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| - | [[Image:2qze.png|left|200px]] | ||
| - | + | ==Monoclinic Mimivirus Capping Enzyme Triphosphatase.== | |
| + | <StructureSection load='2qze' size='340' side='right'caption='[[2qze]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2qze]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mimivirus Mimivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QZE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qze OCA], [https://pdbe.org/2qze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qze RCSB], [https://www.ebi.ac.uk/pdbsum/2qze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qze ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MCE_MIMIV MCE_MIMIV] Responsible for methylating the 5'-cap structure of mRNAs. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The RNA triphosphatase (RTPase) components of the mRNA capping apparatus are a bellwether of eukaryal taxonomy. Fungal and protozoal RTPases belong to the triphosphate tunnel metalloenzyme (TTM) family, exemplified by yeast Cet1. Several large DNA viruses encode metal-dependent RTPases unrelated to the cysteinyl-phosphatase RTPases of their metazoan host organisms. The origins of DNA virus RTPases are unclear because they are structurally uncharacterized. Mimivirus, a giant virus of amoeba, resembles poxviruses in having a trifunctional capping enzyme composed of a metal-dependent RTPase module fused to guanylyltransferase (GTase) and guanine-N7 methyltransferase domains. The crystal structure of mimivirus RTPase reveals a minimized tunnel fold and an active site strikingly similar to that of Cet1. Unlike homodimeric fungal RTPases, mimivirus RTPase is a monomer. The mimivirus TTM-type RTPase-GTase fusion resembles the capping enzymes of amoebae, providing evidence that the ancestral large DNA virus acquired its capping enzyme from a unicellular host. | ||
| - | + | Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domain.,Benarroch D, Smith P, Shuman S Structure. 2008 Apr;16(4):501-12. PMID:18400173<ref>PMID:18400173</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2qze" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | < | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
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| - | [[Category: | + | |
[[Category: Mimivirus]] | [[Category: Mimivirus]] | ||
| - | [[Category: | + | [[Category: Benarroch D]] |
| - | + | [[Category: Shuman S]] | |
| - | + | [[Category: Smith P]] | |
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| - | [[Category: S | + | |
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Current revision
Monoclinic Mimivirus Capping Enzyme Triphosphatase.
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