2qcp

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[[Image:2qcp.png|left|200px]]
 
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{{STRUCTURE_2qcp| PDB=2qcp | SCENE= }}
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==1.0 A Structure of CusF-Ag(I) residues 10-88 from Escherichia coli==
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<StructureSection load='2qcp' size='340' side='right'caption='[[2qcp]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qcp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._W3110 Escherichia coli str. K-12 substr. W3110]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QCP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG:SILVER+ION'>AG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qcp OCA], [https://pdbe.org/2qcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qcp RCSB], [https://www.ebi.ac.uk/pdbsum/2qcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qcp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CUSF_ECOLI CUSF_ECOLI] Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide.<ref>PMID:11399769</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qc/2qcp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qcp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Elevated levels of copper or silver ions in the environment are an immediate threat to many organisms. Escherichia coli is able to resist the toxic effects of these ions through strictly limiting intracellular levels of Cu(I) and Ag(I). The CusCFBA system is one system in E. coli responsible for copper/silver tolerance. A key component of this system is the periplasmic copper/silver-binding protein, CusF. Here the X-ray structure and XAS data on the CusF-Ag(I) and CusF-Cu(I) complexes, respectively, are reported. In the CusF-Ag(I) structure, Ag(I) is coordinated by two methionines and a histidine, with a nearby tryptophan capping the metal site. EXAFS measurements on the CusF-Cu(I) complex show a similar environment for Cu(I). The arrangement of ligands effectively sequesters the metal from its periplasmic environment and thus may play a role in protecting the cell from the toxic ion.
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===1.0 A Structure of CusF-Ag(I) residues 10-88 from Escherichia coli===
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Unusual Cu(I)/Ag(I) coordination of Escherichia coli CusF as revealed by atomic resolution crystallography and X-ray absorption spectroscopy.,Loftin IR, Franke S, Blackburn NJ, McEvoy MM Protein Sci. 2007 Oct;16(10):2287-93. PMID:17893365<ref>PMID:17893365</ref>
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{{ABSTRACT_PUBMED_17893365}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2qcp" style="background-color:#fffaf0;"></div>
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[[2qcp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_str._k-12_substr._w3110 Escherichia coli str. k-12 substr. w3110]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QCP OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:017893365</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Escherichia coli str. k-12 substr. w3110]]
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[[Category: Escherichia coli str. K-12 substr. W3110]]
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[[Category: Loftin, I R.]]
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[[Category: Large Structures]]
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[[Category: Beta barrel]]
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[[Category: Loftin IR]]
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[[Category: Copper-binding]]
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[[Category: Metal binding protein]]
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[[Category: Metal resistance]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotein]]
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[[Category: Ob-fold]]
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[[Category: Periplasmic]]
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[[Category: Silver-binding]]
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Current revision

1.0 A Structure of CusF-Ag(I) residues 10-88 from Escherichia coli

PDB ID 2qcp

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