3a14
From Proteopedia
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| - | [[Image:3a14.png|left|200px]] | ||
| - | + | ==Crystal structure of DXR from Thermotoga maritima, in complex with NADPH== | |
| + | <StructureSection load='3a14' size='340' side='right'caption='[[3a14]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3a14]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A14 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a14 OCA], [https://pdbe.org/3a14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a14 RCSB], [https://www.ebi.ac.uk/pdbsum/3a14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a14 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DXR_THEMA DXR_THEMA] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/3a14_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a14 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[DXP reductoisomerase 3D Structures|DXP reductoisomerase 3D Structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[ | + | |
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| - | [[Category: | + | |
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
| - | [[Category: Noguchi | + | [[Category: Noguchi K]] |
| - | [[Category: Ohsawa | + | [[Category: Ohsawa K]] |
| - | [[Category: Ohtaki | + | [[Category: Ohtaki A]] |
| - | [[Category: Sasaki | + | [[Category: Sasaki Y]] |
| - | [[Category: Takenoya | + | [[Category: Takenoya M]] |
| - | [[Category: Yajima | + | [[Category: Yajima S]] |
| - | [[Category: Yohda | + | [[Category: Yohda M]] |
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Current revision
Crystal structure of DXR from Thermotoga maritima, in complex with NADPH
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Categories: Large Structures | Thermotoga maritima | Noguchi K | Ohsawa K | Ohtaki A | Sasaki Y | Takenoya M | Yajima S | Yohda M
