2q9t

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[[Image:2q9t.png|left|200px]]
 
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{{STRUCTURE_2q9t| PDB=2q9t | SCENE= }}
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==High-resolution structure of the DING protein from Pseudomonas fluorescens==
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<StructureSection load='2q9t' size='340' side='right'caption='[[2q9t]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2q9t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens_SBW25 Pseudomonas fluorescens SBW25]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q9T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.43&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9t OCA], [https://pdbe.org/2q9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q9t RCSB], [https://www.ebi.ac.uk/pdbsum/2q9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q9t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D0VWY2_PSEFS D0VWY2_PSEFS]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q9/2q9t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q9t ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A recombinant DING protein from Pseudomonas fluorescens has been previously shown to have a phosphate-binding site, and to be mitogenic for human cells. Here we report the three-dimensional structure of the protein, confirming a close similarity to the "Venus flytrap" structure seen in other human and bacterial phosphate-binding proteins. Site-directed mutagenesis confirms the role of a key residue involved in phosphate binding, and that the mitogenic activity is not dependent on this property. Deletion of one of the two hinged domains that constitute the Venus flytrap also eliminates phosphate binding whilst enhancing mitogenic activity.
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===High-resolution structure of the DING protein from Pseudomonas fluorescens===
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Structure-function relationships in a bacterial DING protein.,Ahn S, Moniot S, Elias M, Chabriere E, Kim D, Scott K FEBS Lett. 2007 Jul 24;581(18):3455-60. Epub 2007 Jun 27. PMID:17612529<ref>PMID:17612529</ref>
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{{ABSTRACT_PUBMED_17612529}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2q9t" style="background-color:#fffaf0;"></div>
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[[2q9t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9T OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:017612529</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Pseudomonas fluorescens]]
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[[Category: Large Structures]]
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[[Category: Ahn, S.]]
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[[Category: Pseudomonas fluorescens SBW25]]
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[[Category: Chabriere, E.]]
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[[Category: Ahn S]]
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[[Category: Elias, M.]]
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[[Category: Chabriere E]]
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[[Category: Kim, D.]]
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[[Category: Elias M]]
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[[Category: Moniot, S.]]
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[[Category: Kim D]]
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[[Category: Scott, K.]]
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[[Category: Moniot S]]
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[[Category: Ding protein]]
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[[Category: Scott K]]
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[[Category: Phosphate-binding]]
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[[Category: Psts protein]]
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[[Category: Unknown function]]
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[[Category: Venus flytrap fold]]
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Current revision

High-resolution structure of the DING protein from Pseudomonas fluorescens

PDB ID 2q9t

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