This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2yt8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (19:17, 29 May 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2yt8.png|left|200px]]
 
-
{{STRUCTURE_2yt8| PDB=2yt8 | SCENE= }}
+
==Solution structure of the PDZ domain of Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma)==
-
 
+
<StructureSection load='2yt8' size='340' side='right'caption='[[2yt8]]' scene=''>
-
===Solution structure of the PDZ domain of Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma)===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2yt8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YT8 FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yt8 OCA], [https://pdbe.org/2yt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yt8 RCSB], [https://www.ebi.ac.uk/pdbsum/2yt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yt8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2yt8 TOPSAN]</span></td></tr>
-
[[2yt8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YT8 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/APBA3_HUMAN APBA3_HUMAN] May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.<ref>PMID:19726677</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yt/2yt8_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yt8 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Dang, W.]]
+
[[Category: Large Structures]]
-
[[Category: Inoue, M.]]
+
[[Category: Dang W]]
-
[[Category: Kigawa, T.]]
+
[[Category: Inoue M]]
-
[[Category: Muto, Y.]]
+
[[Category: Kigawa T]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Muto Y]]
-
[[Category: Seiki, M.]]
+
[[Category: Seiki M]]
-
[[Category: Shirouzu, M.]]
+
[[Category: Shirouzu M]]
-
[[Category: Tarada, T.]]
+
[[Category: Tarada T]]
-
[[Category: Yokoyama, S.]]
+
[[Category: Yokoyama S]]
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Pdz domain]]
+
-
[[Category: Protein transport]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structure genomic]]
+

Current revision

Solution structure of the PDZ domain of Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma)

PDB ID 2yt8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2yt8"
Personal tools