2r9y

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[[Image:2r9y.png|left|200px]]
 
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{{STRUCTURE_2r9y| PDB=2r9y | SCENE= }}
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==Structure of antiplasmin==
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<StructureSection load='2r9y' size='340' side='right'caption='[[2r9y]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2r9y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9y OCA], [https://pdbe.org/2r9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9y RCSB], [https://www.ebi.ac.uk/pdbsum/2r9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A2AP_MOUSE A2AP_MOUSE] Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r9y ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The serpin alpha(2)-antiplasmin (SERPINF2) is the principal inhibitor of plasmin and inhibits fibrinolysis. Accordingly, alpha(2)-antiplasmin deficiency in humans results in uncontrolled fibrinolysis and a bleeding disorder. alpha(2)-antiplasmin is an unusual serpin, in that it contains extensive N- and C-terminal sequences flanking the serpin domain. The N-terminal sequence is crosslinked to fibrin by factor XIIIa, whereas the C-terminal region mediates the initial interaction with plasmin. To understand how this may happen, we have determined the 2.65A X-ray crystal structure of an N-terminal truncated murine alpha(2)-antiplasmin. The structure reveals that part of the C-terminal sequence is tightly associated with the body of the serpin. This would be anticipated to position the flexible plasmin-binding portion of the C-terminus in close proximity to the serpin Reactive Center Loop where it may act as a template to accelerate serpin/protease interactions.
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===Structure of antiplasmin===
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X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin.,Law RH, Sofian T, Kan WT, Horvath AJ, Hitchen CR, Langendorf CG, Buckle AM, Whisstock JC, Coughlin PB Blood. 2008 Feb 15;111(4):2049-52. Epub 2007 Dec 6. PMID:18063751<ref>PMID:18063751</ref>
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{{ABSTRACT_PUBMED_18063751}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2r9y" style="background-color:#fffaf0;"></div>
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[[2r9y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9Y OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018063751</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Buckle, A M.]]
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[[Category: Buckle AM]]
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[[Category: Coughlin, P B.]]
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[[Category: Coughlin PB]]
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[[Category: Hitchen, C R.]]
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[[Category: Hitchen CR]]
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[[Category: Horvath, A J.]]
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[[Category: Horvath AJ]]
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[[Category: Kan, W T.]]
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[[Category: Kan WT]]
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[[Category: Langendorf, C G.]]
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[[Category: Langendorf CG]]
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[[Category: Law, R H.P.]]
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[[Category: Law RHP]]
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[[Category: Sofian, T.]]
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[[Category: Sofian T]]
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[[Category: Whisstock, J C.]]
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[[Category: Whisstock JC]]
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[[Category: Acute phase]]
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[[Category: Alpha2-antiplasmin]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Inhibitory serpin]]
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[[Category: Plasmin inhibitor]]
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[[Category: Protease inhibitor]]
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[[Category: Secreted]]
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[[Category: Serine protease inhibitor]]
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[[Category: Sulfation]]
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[[Category: Toxin]]
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Current revision

Structure of antiplasmin

PDB ID 2r9y

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