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3al6

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[[Image:3al6.png|left|200px]]
 
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{{STRUCTURE_3al6| PDB=3al6 | SCENE= }}
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==Crystal structure of Human TYW5==
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<StructureSection load='3al6' size='340' side='right'caption='[[3al6]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===Crystal structure of Human TYW5===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3al6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AL6 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20972222}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3al6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3al6 OCA], [https://pdbe.org/3al6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3al6 RCSB], [https://www.ebi.ac.uk/pdbsum/3al6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3al6 ProSAT]</span></td></tr>
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[[3al6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AL6 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/TYW5_HUMAN TYW5_HUMAN] tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.<ref>PMID:20739293</ref>
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<ref group="xtra">PMID:020972222</ref><references group="xtra"/>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Araiso, Y.]]
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[[Category: Large Structures]]
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[[Category: Ishitani, R.]]
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[[Category: Araiso Y]]
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[[Category: Kato, M.]]
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[[Category: Ishitani R]]
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[[Category: Nureki, O.]]
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[[Category: Kato M]]
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[[Category: Trna modification enzyme]]
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[[Category: Nureki O]]
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[[Category: Unknown function]]
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Current revision

Crystal structure of Human TYW5

PDB ID 3al6

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