2wqk

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[[Image:2wqk.png|left|200px]]
 
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{{STRUCTURE_2wqk| PDB=2wqk | SCENE= }}
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==Crystal Structure of Sure Protein from Aquifex aeolicus==
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<StructureSection load='2wqk' size='340' side='right'caption='[[2wqk]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wqk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2phj 2phj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqk OCA], [https://pdbe.org/2wqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wqk RCSB], [https://www.ebi.ac.uk/pdbsum/2wqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SURE_AQUAE SURE_AQUAE] Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/2wqk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wqk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SurE is a stationary-phase survival protein found in bacteria, eukaryotes and archaea that exhibits a divalent-metal-ion-dependent phosphatase activity and acts as a nucleotidase and polyphosphate phosphohydrolase. The structure of the SurE protein from the hyperthermophile Aquifex aeolicus has been solved at 1.5 A resolution using molecular replacement with one dimer in the asymmetric unit and refined to an R factor of 15.6%. The crystal packing reveals that two dimers assemble to form a tetramer, although gel-filtration chromatography showed the presence of only a dimer in solution. The phosphatase active-site pocket was occupied by sulfate ions from the crystallization medium.
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===CRYSTAL STRUCTURE OF SURE PROTEIN FROM AQUIFEX AEOLICUS===
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Structure of SurE protein from Aquifex aeolicus VF5 at 1.5 A resolution.,Antonyuk SV, Ellis MJ, Strange RW, Bessho Y, Kuramitsu S, Shinkai A, Yokoyama S, Hasnain SS Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt, 12):1204-8. Epub 2009 Nov 27. PMID:20054112<ref>PMID:20054112</ref>
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{{ABSTRACT_PUBMED_20054112}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2wqk" style="background-color:#fffaf0;"></div>
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[[2wqk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2phj 2phj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQK OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:020054112</ref><references group="xtra"/>
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</StructureSection>
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[[Category: 5'-nucleotidase]]
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[[Category: Aquifex aeolicus VF5]]
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[[Category: Aquifex aeolicus]]
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[[Category: Large Structures]]
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[[Category: Antonyuk, S V.]]
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[[Category: Antonyuk SV]]
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[[Category: Bessho, Y.]]
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[[Category: Bessho Y]]
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[[Category: Ellis, M J.]]
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[[Category: Ellis MJ]]
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[[Category: Hasnain, S S.]]
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[[Category: Hasnain SS]]
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[[Category: Kuramitsu, S.]]
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[[Category: Kuramitsu S]]
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[[Category: Rsgi , Riken Structural Genomics Proteomics Initiative]]
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[[Category: Strange RW]]
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[[Category: Strange, R W.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: 3-d structure]]
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[[Category: Hydrolase]]
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[[Category: Mixed alpha/beta protein]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Putative acid phosphatase]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Sure protein]]
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Current revision

Crystal Structure of Sure Protein from Aquifex aeolicus

PDB ID 2wqk

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