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2x2s

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[[Image:2x2s.png|left|200px]]
 
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{{STRUCTURE_2x2s| PDB=2x2s | SCENE= }}
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==Crystal structure of Sclerotinia sclerotiorum agglutinin SSA==
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<StructureSection load='2x2s' size='340' side='right'caption='[[2x2s]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2x2s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sclerotinia_sclerotiorum Sclerotinia sclerotiorum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X2S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2s OCA], [https://pdbe.org/2x2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x2s RCSB], [https://www.ebi.ac.uk/pdbsum/2x2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x2s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AGGL_SCLSC AGGL_SCLSC] Lectin that primarily recognizes glycans with a non-reducing terminal N-acetylgalactosamine (GalNAc), with a preference for the alpha- over the beta-anomer. Can also bind non-reducing terminal galactose (Gal) residues but with a lower affinity. Strongly interacts with glycolipid type glycans with terminal non-reducing Gal or GalNAc but fails to bind sialylated or fucosylated forms of the same glycans. Strongly interacts with galactosylated N-glycans, displaying highest affinity for alpha-1-3 branched mono-antennary N-glycans but also binding to multi-antennary glycans.<ref>PMID:12901882</ref> <ref>PMID:17294128</ref> <ref>PMID:20566411</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/2x2s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x2s ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF SCLEROTINIA SCLEROTIORUM AGGLUTININ SSA===
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==See Also==
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*[[Agglutinin 3D structures|Agglutinin 3D structures]]
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{{ABSTRACT_PUBMED_20566411}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2x2s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sclerotinia_sclerotiorum Sclerotinia sclerotiorum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2S OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:020566411</ref><references group="xtra"/>
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[[Category: Sclerotinia sclerotiorum]]
[[Category: Sclerotinia sclerotiorum]]
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[[Category: Bourne, Y.]]
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[[Category: Bourne Y]]
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[[Category: Damme, E J.M Van.]]
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[[Category: Peumans WJ]]
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[[Category: Peumans, W J.]]
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[[Category: Roig-Zamboni V]]
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[[Category: Roig-Zamboni, V.]]
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[[Category: Rouge P]]
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[[Category: Rouge, P.]]
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[[Category: Sulzenbacher G]]
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[[Category: Sulzenbacher, G.]]
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[[Category: Van Damme EJM]]
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[[Category: Beta-trefoil domain]]
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[[Category: Cell adhesion]]
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[[Category: Fungal lectin]]
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Current revision

Crystal structure of Sclerotinia sclerotiorum agglutinin SSA

PDB ID 2x2s

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