2rol
From Proteopedia
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| - | [[Image:2rol.png|left|200px]] | ||
| - | + | ==Structural Basis of PxxDY motif recognition in SH3 binding== | |
| - | + | <StructureSection load='2rol' size='340' side='right'caption='[[2rol]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2rol]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ROL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rol OCA], [https://pdbe.org/2rol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rol RCSB], [https://www.ebi.ac.uk/pdbsum/2rol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rol ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2rol]] is a 2 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/ES8L1_HUMAN ES8L1_HUMAN] Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.<ref>PMID:14565974</ref> | |
| - | == | + | == Evolutionary Conservation == |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2rol_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rol ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Aitio | + | [[Category: Large Structures]] |
| - | [[Category: Hellman | + | [[Category: Aitio O]] |
| - | [[Category: Kesti | + | [[Category: Hellman M]] |
| - | [[Category: Kleino | + | [[Category: Kesti T]] |
| - | [[Category: Paakkonen | + | [[Category: Kleino I]] |
| - | [[Category: Permi | + | [[Category: Paakkonen K]] |
| - | [[Category: Saksela | + | [[Category: Permi P]] |
| - | [[Category: Samuilova | + | [[Category: Saksela K]] |
| - | [[Category: Tossavainen | + | [[Category: Samuilova O]] |
| - | + | [[Category: Tossavainen H]] | |
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Current revision
Structural Basis of PxxDY motif recognition in SH3 binding
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Categories: Homo sapiens | Large Structures | Aitio O | Hellman M | Kesti T | Kleino I | Paakkonen K | Permi P | Saksela K | Samuilova O | Tossavainen H
