2v9a

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[[Image:2v9a.png|left|200px]]
 
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{{STRUCTURE_2v9a| PDB=2v9a | SCENE= }}
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==Structure of Citrate-free Periplasmic Domain of Sensor Histidine Kinase CitA==
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<StructureSection load='2v9a' size='340' side='right'caption='[[2v9a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2v9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V9A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9a OCA], [https://pdbe.org/2v9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v9a RCSB], [https://www.ebi.ac.uk/pdbsum/2v9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CITA_KLEPN CITA_KLEPN] Member of the two-component regulatory system CitA/CitB. Probably activates CitB by phosphorylation. The periplasmic domain binds H-citrate(2-), which is essential for induction of the citrate-fermentation genes.<ref>PMID:10447894</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v9a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v9a ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sensor histidine kinases of two-component signal-transduction systems are essential for bacteria to adapt to variable environmental conditions. However, despite their prevalence, it is not well understood how extracellular signals such as ligand binding regulate the activity of these sensor kinases. CitA is the sensor histidine kinase in Klebsiella pneumoniae that regulates the transport and anaerobic metabolism of citrate in response to its extracellular concentration. We report here the X-ray structures of the periplasmic sensor domain of CitA in the citrate-free and citrate-bound states. A comparison of the two structures shows that ligand binding causes a considerable contraction of the sensor domain. This contraction may represent the molecular switch that activates transmembrane signaling in the receptor.
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===STRUCTURE OF CITRATE-FREE PERIPLASMIC DOMAIN OF SENSOR HISTIDINE KINASE CITA===
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A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA.,Sevvana M, Vijayan V, Zweckstetter M, Reinelt S, Madden DR, Herbst-Irmer R, Sheldrick GM, Bott M, Griesinger C, Becker S J Mol Biol. 2008 Mar 21;377(2):512-23. Epub 2008 Jan 16. PMID:18258261<ref>PMID:18258261</ref>
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{{ABSTRACT_PUBMED_18258261}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2v9a" style="background-color:#fffaf0;"></div>
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[[2v9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9A OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018258261</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Histidine kinase]]
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[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: Becker, S.]]
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[[Category: Large Structures]]
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[[Category: Bott, M.]]
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[[Category: Becker S]]
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[[Category: Griesinger, C.]]
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[[Category: Bott M]]
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[[Category: Madden, D R.]]
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[[Category: Griesinger C]]
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[[Category: Reinelt, S.]]
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[[Category: Madden DR]]
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[[Category: Sevvana, M.]]
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[[Category: Reinelt S]]
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[[Category: Sheldrick, G M.]]
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[[Category: Sevvana M]]
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[[Category: Vijayan, V.]]
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[[Category: Sheldrick GM]]
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[[Category: Zweckstetter, M.]]
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[[Category: Vijayan V]]
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[[Category: Cita]]
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[[Category: Zweckstetter M]]
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[[Category: Inner membrane]]
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[[Category: Kinase]]
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[[Category: Membrane]]
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[[Category: Phosphorylation]]
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[[Category: Sensor domain]]
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[[Category: Sensor histidine kinase]]
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[[Category: Signal transduction]]
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[[Category: Transferase]]
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[[Category: Transmembrane]]
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[[Category: Two-component regulatory system]]
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Current revision

Structure of Citrate-free Periplasmic Domain of Sensor Histidine Kinase CitA

PDB ID 2v9a

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