2qdf

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[[Image:2qdf.png|left|200px]]
 
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{{STRUCTURE_2qdf| PDB=2qdf | SCENE= }}
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==Structure of N-terminal domain of E. Coli YaeT==
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<StructureSection load='2qdf' size='340' side='right'caption='[[2qdf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qdf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QDF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qdf OCA], [https://pdbe.org/2qdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qdf RCSB], [https://www.ebi.ac.uk/pdbsum/2qdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qdf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BAMA_ECOLI BAMA_ECOLI] Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.<ref>PMID:15951436</ref> <ref>PMID:16102012</ref> <ref>PMID:16824102</ref> <ref>PMID:20378773</ref> <ref>PMID:21823654</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qd/2qdf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qdf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Integral beta-barrel proteins are found in the outer membranes of mitochondria, chloroplasts, and Gram-negative bacteria. The machine that assembles these proteins contains an integral membrane protein, called YaeT in Escherichia coli, which has one or more polypeptide transport-associated (POTRA) domains. The crystal structure of a periplasmic fragment of YaeT reveals the POTRA domain fold and suggests a model for how POTRA domains can bind different peptide sequences, as required for a machine that handles numerous beta-barrel protein precursors. Analysis of POTRA domain deletions shows which are essential and provides a view of the spatial organization of this assembly machine.
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===Structure of N-terminal domain of E. Coli YaeT===
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Structure and function of an essential component of the outer membrane protein assembly machine.,Kim S, Malinverni JC, Sliz P, Silhavy TJ, Harrison SC, Kahne D Science. 2007 Aug 17;317(5840):961-4. PMID:17702946<ref>PMID:17702946</ref>
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{{ABSTRACT_PUBMED_17702946}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2qdf" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2qdf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QDF OCA].
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*[[Bam complex 3D structures|Bam complex 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017702946</ref><references group="xtra"/>
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__TOC__
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[[Category: Escherichia coli k-12]]
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</StructureSection>
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[[Category: Harrison, S C.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Kahne, D.]]
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[[Category: Large Structures]]
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[[Category: Kim, S.]]
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[[Category: Harrison SC]]
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[[Category: Malinverni, J C.]]
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[[Category: Kahne D]]
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[[Category: Silhavy, T J.]]
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[[Category: Kim S]]
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[[Category: Sliz, P.]]
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[[Category: Malinverni JC]]
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[[Category: Membrane protein]]
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[[Category: Silhavy TJ]]
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[[Category: Potra domain]]
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[[Category: Sliz P]]
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[[Category: Protein transport]]
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Current revision

Structure of N-terminal domain of E. Coli YaeT

PDB ID 2qdf

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