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2z0i

From Proteopedia

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[[Image:2z0i.png|left|200px]]
 
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{{STRUCTURE_2z0i| PDB=2z0i | SCENE= }}
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==Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculus==
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<StructureSection load='2z0i' size='340' side='right'caption='[[2z0i]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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===Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculus===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2z0i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z0I FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[2z0i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0I OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z0i OCA], [https://pdbe.org/2z0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z0i RCSB], [https://www.ebi.ac.uk/pdbsum/2z0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z0i ProSAT], [https://www.topsan.org/Proteins/RSGI/2z0i TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEM2_MOUSE HEM2_MOUSE] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/2z0i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z0i ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Porphobilinogen synthase|Porphobilinogen synthase]]
*[[Porphobilinogen synthase|Porphobilinogen synthase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Porphobilinogen synthase]]
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[[Category: Kawazoe M]]
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[[Category: Kawazoe, M.]]
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[[Category: Kishishita S]]
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[[Category: Kishishita, S.]]
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[[Category: Murayama K]]
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[[Category: Murayama, K.]]
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[[Category: Shirouzu M]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Takemoto C]]
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[[Category: Shirouzu, M.]]
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[[Category: Terada T]]
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[[Category: Takemoto, C.]]
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[[Category: Wang H]]
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[[Category: Terada, T.]]
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[[Category: Xie Y]]
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[[Category: Wang, H.]]
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[[Category: Yokoyama S]]
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[[Category: Xie, Y.]]
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[[Category: Yokoyama, S.]]
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[[Category: Dehydratase]]
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[[Category: Lyase]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Tetrapyrrole biosynthesis]]
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Current revision

Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculus

PDB ID 2z0i

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