2vpy

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[[Image:2vpy.png|left|200px]]
 
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{{STRUCTURE_2vpy| PDB=2vpy | SCENE= }}
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==Polysulfide reductase with bound quinone inhibitor, pentachlorophenol (PCP)==
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<StructureSection load='2vpy' size='340' side='right'caption='[[2vpy]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2vpy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VPY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGD:2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE+GUANOSINE+DINUCLEOTIDE'>MGD</scene>, <scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=PCI:PENTACHLOROPHENOL'>PCI</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpy OCA], [https://pdbe.org/2vpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vpy RCSB], [https://www.ebi.ac.uk/pdbsum/2vpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vpy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q72LA4_THET2 Q72LA4_THET2]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vpy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vpy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacterial polysulfide reductase (PsrABC) is an integral membrane protein complex responsible for quinone-coupled reduction of polysulfide, a process important in extreme environments such as deep-sea vents and hot springs. We determined the structure of polysulfide reductase from Thermus thermophilus at 2.4-A resolution, revealing how the PsrA subunit recognizes and reduces its unique polyanionic substrate. The integral membrane subunit PsrC was characterized using the natural substrate menaquinone-7 and inhibitors, providing a comprehensive representation of a quinone binding site and revealing the presence of a water-filled cavity connecting the quinone binding site on the periplasmic side to the cytoplasm. These results suggest that polysulfide reductase could be a key energy-conserving enzyme of the T. thermophilus respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane via a previously unknown mechanism.
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===POLYSULFIDE REDUCTASE WITH BOUND QUINONE INHIBITOR, PENTACHLOROPHENOL (PCP)===
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Molecular mechanism of energy conservation in polysulfide respiration.,Jormakka M, Yokoyama K, Yano T, Tamakoshi M, Akimoto S, Shimamura T, Curmi P, Iwata S Nat Struct Mol Biol. 2008 Jul;15(7):730-7. Epub 2008 Jun 8. PMID:18536726<ref>PMID:18536726</ref>
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{{ABSTRACT_PUBMED_18536726}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2vpy" style="background-color:#fffaf0;"></div>
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[[2vpy]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPY OCA].
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== References ==
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[[Category: Thermus thermophilus]]
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<references/>
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[[Category: Akimoto, S.]]
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__TOC__
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[[Category: Curmi, P.]]
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</StructureSection>
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[[Category: Iwata, S.]]
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[[Category: Large Structures]]
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[[Category: Jormakka, M.]]
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[[Category: Thermus thermophilus HB27]]
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[[Category: Shimamura, T.]]
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[[Category: Akimoto S]]
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[[Category: Tamakoshi, M.]]
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[[Category: Curmi P]]
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[[Category: Yano, T.]]
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[[Category: Iwata S]]
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[[Category: Yokoyama, K.]]
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[[Category: Jormakka M]]
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[[Category: Fe4s4]]
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[[Category: Shimamura T]]
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[[Category: Integral membrane protein]]
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[[Category: Tamakoshi M]]
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[[Category: Iron]]
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[[Category: Yano T]]
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[[Category: Iron sulfur cluster]]
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[[Category: Yokoyama K]]
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[[Category: Iron-sulfur]]
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[[Category: Metal-binding]]
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[[Category: Mgd]]
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[[Category: Molybdenum]]
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[[Category: Molybdopterin]]
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[[Category: Molybdopterin guanine dinucleotide]]
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[[Category: Mpt]]
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[[Category: Oxidoreductase]]
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Current revision

Polysulfide reductase with bound quinone inhibitor, pentachlorophenol (PCP)

PDB ID 2vpy

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