This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2yt4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2yt4" [edit=sysop:move=sysop])
Current revision (13:54, 13 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2yt4.png|left|200px]]
 
-
{{STRUCTURE_2yt4| PDB=2yt4 | SCENE= }}
+
==Crystal structure of human DGCR8 core==
-
 
+
<StructureSection load='2yt4' size='340' side='right'caption='[[2yt4]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
===Crystal structure of human DGCR8 core===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2yt4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YT4 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_17704815}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yt4 OCA], [https://pdbe.org/2yt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yt4 RCSB], [https://www.ebi.ac.uk/pdbsum/2yt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yt4 ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[2yt4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YT4 OCA].
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/DGCR8_HUMAN DGCR8_HUMAN] Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Involved in the silencing of embryonic stem cells self-renewal.<ref>PMID:15589161</ref> <ref>PMID:15574589</ref> <ref>PMID:15531877</ref> <ref>PMID:16751099</ref> <ref>PMID:16906129</ref> <ref>PMID:16963499</ref> <ref>PMID:17159994</ref>
-
==Reference==
+
== Evolutionary Conservation ==
-
<ref group="xtra">PMID:017704815</ref><references group="xtra"/>
+
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yt/2yt4_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yt4 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Cho, Y.]]
+
[[Category: Large Structures]]
-
[[Category: Sohn, S Y.]]
+
[[Category: Cho Y]]
-
[[Category: Dsrbd]]
+
[[Category: Sohn SY]]
-
[[Category: Rna binding domain]]
+
-
[[Category: Rna binding protein]]
+

Current revision

Crystal structure of human DGCR8 core

PDB ID 2yt4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2yt4"
Personal tools