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2r7n

From Proteopedia

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[[Image:2r7n.png|left|200px]]
 
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{{STRUCTURE_2r7n| PDB=2r7n | SCENE= }}
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==Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ADP and FAICAR==
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<StructureSection load='2r7n' size='340' side='right'caption='[[2r7n]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ADP and FAICAR===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2r7n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R7N FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18069798}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAI:5-(FORMYLAMINO)-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXAMIDE'>FAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r7n OCA], [https://pdbe.org/2r7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r7n RCSB], [https://www.ebi.ac.uk/pdbsum/2r7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r7n ProSAT]</span></td></tr>
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[[2r7n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R7N OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/PURP_METJA PURP_METJA] Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.<ref>PMID:15623504</ref>
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<ref group="xtra">PMID:018069798</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r7/2r7n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r7n ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Ealick, S E.]]
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[[Category: Ealick SE]]
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[[Category: White, R H.]]
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[[Category: White RH]]
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[[Category: Zhang, Y.]]
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[[Category: Zhang Y]]
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[[Category: Atp-binding]]
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[[Category: Atp-grasp superfamily]]
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[[Category: Ligase]]
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[[Category: Magnesium]]
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[[Category: Manganese]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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Current revision

Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ADP and FAICAR

PDB ID 2r7n

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