3dez

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[[Image:3dez.png|left|200px]]
 
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{{STRUCTURE_3dez| PDB=3dez | SCENE= }}
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==Crystal structure of Orotate phosphoribosyltransferase from Streptococcus mutans==
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<StructureSection load='3dez' size='340' side='right'caption='[[3dez]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3dez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DEZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dez OCA], [https://pdbe.org/3dez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dez RCSB], [https://www.ebi.ac.uk/pdbsum/3dez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dez ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYRE_STRMU PYRE_STRMU] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/3dez_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dez ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Orotate phosphoribosyltransferase (OPRTase) catalyzes the OMP-forming step in de novo pyrimidine-nucleotide biosynthesis. Here, the crystal structure of OPRTase from the caries pathogen Streptococcus mutans is reported at 2.4 A resolution. S. mutans OPRTase forms a symmetric dimer and each monomer binds two sulfates at the active sites. The structural symmetry of the sulfate-binding sites and the missing loops in this structure are consistent with a symmetric catalysis mechanism.
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===Crystal structure of Orotate phosphoribosyltransferase from Streptococcus mutans===
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Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans.,Liu CP, Xu R, Gao ZQ, Xu JH, Hou HF, Li LQ, She Z, Li LF, Su XD, Liu P, Dong YH Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt, 5):498-502. Epub 2010 Apr 29. PMID:20445243<ref>PMID:20445243</ref>
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{{ABSTRACT_PUBMED_20445243}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3dez" style="background-color:#fffaf0;"></div>
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[[3dez]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DEZ OCA].
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==See Also==
==See Also==
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*[[Phosphoribosyltransferase|Phosphoribosyltransferase]]
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020445243</ref><references group="xtra"/>
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__TOC__
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[[Category: Orotate phosphoribosyltransferase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptococcus mutans]]
[[Category: Streptococcus mutans]]
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[[Category: Dong, Y H.]]
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[[Category: Dong YH]]
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[[Category: Gao, Z Q.]]
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[[Category: Gao ZQ]]
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[[Category: Hou, H F.]]
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[[Category: Hou HF]]
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[[Category: Li, L F.]]
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[[Category: Li LF]]
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[[Category: Liu, C P.]]
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[[Category: Liu CP]]
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[[Category: Su, X D.]]
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[[Category: Su XD]]
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[[Category: Glycosyltransferase]]
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[[Category: Magnesium]]
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[[Category: Orotate phosphoribosyltransferase]]
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[[Category: Pyrimidine biosynthesis]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Orotate phosphoribosyltransferase from Streptococcus mutans

PDB ID 3dez

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