3c3q

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[[Image:3c3q.png|left|200px]]
 
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{{STRUCTURE_3c3q| PDB=3c3q | SCENE= }}
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==ALIX Bro1-domain:CHMIP4B co-crystal structure==
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<StructureSection load='3c3q' size='340' side='right'caption='[[3c3q]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===ALIX Bro1-domain:CHMIP4B co-crystal structure===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3c3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C3Q FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18511562}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c3q OCA], [https://pdbe.org/3c3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c3q RCSB], [https://www.ebi.ac.uk/pdbsum/3c3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c3q ProSAT]</span></td></tr>
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[[3c3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C3Q OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/PDC6I_HUMAN PDC6I_HUMAN] Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.<ref>PMID:14505569</ref> <ref>PMID:14505570</ref> <ref>PMID:14739459</ref> <ref>PMID:17853893</ref> <ref>PMID:17428861</ref> <ref>PMID:17556548</ref>
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<ref group="xtra">PMID:018511562</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c3/3c3q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c3q ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fisher, R D.]]
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[[Category: Large Structures]]
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[[Category: Hill, C P.]]
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[[Category: Fisher RD]]
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[[Category: McCullough, J B.]]
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[[Category: Hill CP]]
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[[Category: Sundquist, W I.]]
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[[Category: McCullough JB]]
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[[Category: Whitby, F G.]]
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[[Category: Sundquist WI]]
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[[Category: Alix chmp4b bro1 amphipathic-helix]]
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[[Category: Whitby FG]]
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[[Category: Apoptosis]]
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[[Category: Cataract]]
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[[Category: Disease mutation]]
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[[Category: Host-virus interaction]]
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[[Category: Protein transport]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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Current revision

ALIX Bro1-domain:CHMIP4B co-crystal structure

PDB ID 3c3q

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