2r65

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[[Image:2r65.png|left|200px]]
 
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{{STRUCTURE_2r65| PDB=2r65 | SCENE= }}
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==Crystal structure of Helicobacter pylori ATP dependent protease, FtsH ADP complex==
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<StructureSection load='2r65' size='340' side='right'caption='[[2r65]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2r65]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R65 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r65 OCA], [https://pdbe.org/2r65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r65 RCSB], [https://www.ebi.ac.uk/pdbsum/2r65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r65 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FTSH_HELPY FTSH_HELPY] Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity).[HAMAP-Rule:MF_01458]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/2r65_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r65 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The ATP-dependent protease, FtsH, degrades misassembled membrane proteins for quality control like SecY, subunit a of FoF1-ATPase, and YccA, and digests short-lived soluble proteins in order to control their cellular regulation, including sigma32, LpxC and lambdacII. The FtsH protein has an N-terminal transmembrane segment and a large cytosolic region that consists of two domains, an ATPase and a protease domain. To provide a structural basis for the nucleotide-dependent domain motions and a better understanding of substrate translocation, the crystal structures of the Helicobacter pylori (Hp) FtsH ATPase domain in the nucleotide-free state and complexed with ADP, were determined. Two different structures of HpFtsH ATPase were observed, with the nucleotide-free state in an asymmetric unit, and these structures reveal the new forms and show other conformational differences between the nucleotide-free and ADP-bound state compared with previous structures. In particular, one HpFtsH Apo structure has a considerable rotation difference compared with the HpFtsH ADP complex, and this large conformational change reveals that FtsH may have the mechanical force needed for substrate translocation.
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===Crystal structure of Helicobacter pylori ATP dependent protease, FtsH ADP complex===
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Structural studies on Helicobacter pyloriATP-dependent protease, FtsH.,Kim SH, Kang GB, Song HE, Park SJ, Bea MH, Eom SH J Synchrotron Radiat. 2008 May;15(Pt 3):208-10. Epub 2008 Apr 18. PMID:18421140<ref>PMID:18421140</ref>
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{{ABSTRACT_PUBMED_18421140}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2r65" style="background-color:#fffaf0;"></div>
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[[2r65]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R65 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018421140</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Helicobacter pylori]]
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[[Category: Bae, M H.]]
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[[Category: Eom, S H.]]
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[[Category: Kang, G B.]]
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[[Category: Kim, S H.]]
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[[Category: Park, S J.]]
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[[Category: Song, H E.]]
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[[Category: Adp]]
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[[Category: Atp-binding]]
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[[Category: Atpase domain]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Ftsh]]
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[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Hydrolase]]
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[[Category: Large Structures]]
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[[Category: Membrane]]
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[[Category: Bae M-H]]
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[[Category: Metal-binding]]
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[[Category: Eom SH]]
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[[Category: Metalloprotease]]
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[[Category: Kang GB]]
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[[Category: Nucleotide-binding]]
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[[Category: Kim SH]]
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[[Category: Protease]]
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[[Category: Park SJ]]
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[[Category: Transmembrane]]
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[[Category: Song H-E]]

Current revision

Crystal structure of Helicobacter pylori ATP dependent protease, FtsH ADP complex

PDB ID 2r65

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