2w51

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[[Image:2w51.png|left|200px]]
 
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{{STRUCTURE_2w51| PDB=2w51 | SCENE= }}
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==Human mesencephalic astrocyte-derived neurotrophic factor (MANF)==
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<StructureSection load='2w51' size='340' side='right'caption='[[2w51]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===HUMAN MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR (MANF)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2w51]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W51 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19258449}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w51 OCA], [https://pdbe.org/2w51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w51 RCSB], [https://www.ebi.ac.uk/pdbsum/2w51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w51 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2w51]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W51 OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN] Familial pancreatic carcinoma.
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==Reference==
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== Function ==
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<ref group="xtra">PMID:019258449</ref><references group="xtra"/>
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[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN] Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.<ref>PMID:12794311</ref> <ref>PMID:18561914</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w51_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w51 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Goldman, A.]]
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[[Category: Large Structures]]
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[[Category: Kalkkinen, N.]]
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[[Category: Goldman A]]
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[[Category: Leppanen, V M.]]
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[[Category: Kalkkinen N]]
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[[Category: Lindholm, P.]]
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[[Category: Leppanen VM]]
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[[Category: Oksanen, E.]]
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[[Category: Lindholm P]]
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[[Category: Parkash, V.]]
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[[Category: Oksanen E]]
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[[Category: Peranen, J.]]
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[[Category: Parkash V]]
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[[Category: Saarma, M.]]
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[[Category: Peranen J]]
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[[Category: Cdnf]]
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[[Category: Saarma M]]
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[[Category: Er stress]]
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[[Category: Glycoprotein]]
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[[Category: Growth factor]]
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[[Category: Hormone]]
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[[Category: Manf]]
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[[Category: Neurotrophic factor]]
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[[Category: Phosphoprotein]]
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[[Category: Saposin]]
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[[Category: Secreted]]
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[[Category: Sialic acid]]
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Current revision

Human mesencephalic astrocyte-derived neurotrophic factor (MANF)

PDB ID 2w51

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