2zug

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[[Image:2zug.png|left|200px]]
 
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{{STRUCTURE_2zug| PDB=2zug | SCENE= }}
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==Crystal structure of WSSV ICP11==
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<StructureSection load='2zug' size='340' side='right'caption='[[2zug]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2zug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shrimp_white_spot_syndrome_virus Shrimp white spot syndrome virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZUG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zug OCA], [https://pdbe.org/2zug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zug RCSB], [https://www.ebi.ac.uk/pdbsum/2zug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zug ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q91LD0_9VIRU Q91LD0_9VIRU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zu/2zug_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zug ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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White spot syndrome virus (WSSV) is a large ( approximately 300 kbp), double-stranded DNA eukaryotic virus that has caused serious disease in crustaceans worldwide. ICP11 is the most highly expressed WSSV nonstructural gene/protein, which strongly suggests its importance in WSSV infection; but until now, its function has remained obscure. We show here that ICP11 acts as a DNA mimic. In crystal, ICP11 formed a polymer of dimers with 2 rows of negatively charged spots that approximated the duplex arrangement of the phosphate groups in DNA. Functionally, ICP11 prevented DNA from binding to histone proteins H2A, H2B, H3, and H2A.x, and in hemocytes from WSSV-infected shrimp, ICP11 colocalized with histone H3 and activated-H2A.x. These observations together suggest that ICP11 might interfere with nucleosome assembly and prevent H2A.x from fulfilling its critical function of repairing DNA double strand breaks. Therefore, ICP11 possesses a functionality that is unique among the handful of presently known DNA mimic proteins.
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===Crystal structure of WSSV ICP11===
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White spot syndrome virus protein ICP11: A histone-binding DNA mimic that disrupts nucleosome assembly.,Wang HC, Wang HC, Ko TP, Lee YM, Leu JH, Ho CH, Huang WP, Lo CF, Wang AH Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20758-63. Epub 2008 Dec 18. PMID:19095797<ref>PMID:19095797</ref>
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{{ABSTRACT_PUBMED_19095797}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2zug" style="background-color:#fffaf0;"></div>
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[[2zug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shrimp_white_spot_syndrome_virus Shrimp white spot syndrome virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZUG OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019095797</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Shrimp white spot syndrome virus]]
[[Category: Shrimp white spot syndrome virus]]
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[[Category: Ko, T P.]]
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[[Category: Ko T-P]]
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[[Category: Lo, C F.]]
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[[Category: Lo C-F]]
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[[Category: Wang, A H.J.]]
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[[Category: Wang AH-J]]
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[[Category: Wang, H C.]]
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[[Category: Wang H-C]]
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[[Category: Dimer]]
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[[Category: Dna mimic protein]]
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[[Category: Viral protein]]
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[[Category: White spot syndrome virus]]
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Current revision

Crystal structure of WSSV ICP11

PDB ID 2zug

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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