3bk3

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[[Image:3bk3.png|left|200px]]
 
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{{STRUCTURE_3bk3| PDB=3bk3 | SCENE= }}
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==Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of Crossveinless-2==
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<StructureSection load='3bk3' size='340' side='right'caption='[[3bk3]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bk3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BK3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bk3 OCA], [https://pdbe.org/3bk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bk3 RCSB], [https://www.ebi.ac.uk/pdbsum/3bk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bk3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN] Induces cartilage and bone formation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/3bk3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bk3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Crossveinless 2 (CV-2) is an extracellular BMP modulator protein belonging to the Chordin family. During development it is expressed at sites of high BMP signaling and like Chordin CV-2 can either enhance or inhibit BMP activity. CV-2 binds to BMP-2 via its N-terminal Von Willebrand factor type C (VWC) domain 1. Here we report the structure of the complex between CV-2 VWC1 and BMP-2. The tripartite VWC1 binds BMP-2 only through a short N-terminal segment, called clip, and subdomain (SD) 1. Mutational analysis establishes that the clip segment and SD1 together create high-affinity BMP-2 binding. All four receptor-binding sites of BMP-2 are blocked in the complex, demonstrating that VWC1 acts as competitive inhibitor for all receptor types. In vivo experiments reveal that the BMP-enhancing (pro-BMP) activity of CV-2 is independent of BMP-2 binding by VWC1, showing that pro- and anti-BMP activities are structurally separated in CV-2.
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===Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of Crossveinless-2===
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Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding.,Zhang JL, Qiu LY, Kotzsch A, Weidauer S, Patterson L, Hammerschmidt M, Sebald W, Mueller TD Dev Cell. 2008 May;14(5):739-50. PMID:18477456<ref>PMID:18477456</ref>
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{{ABSTRACT_PUBMED_18477456}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3bk3" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3bk3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK3 OCA].
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*[[Bone morphogenetic protein 3D structures|Bone morphogenetic protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018477456</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Danio rerio]]
[[Category: Danio rerio]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Mueller, T D.]]
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[[Category: Large Structures]]
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[[Category: Sebald, W.]]
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[[Category: Mueller TD]]
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[[Category: Zhang, J L.]]
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[[Category: Sebald W]]
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[[Category: Bmp inhibitor]]
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[[Category: Zhang J-L]]
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[[Category: Bmp modulator protein]]
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[[Category: Chondrogenesis]]
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[[Category: Chordin]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Cytokine]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Glycoprotein]]
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[[Category: Growth factor]]
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[[Category: Hormone-growth factor complex]]
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[[Category: Osteogenesis]]
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[[Category: Secreted]]
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[[Category: Tgf-beta superfamily]]
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Current revision

Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of Crossveinless-2

PDB ID 3bk3

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